Abstract: Objective To explore the value of preoperative systemic inflammation response index(SIRI) in evaluating the prognosis of patients with gallbladder cancer.
Methods From January 2009 to February 2019,126 patients with gallbladder cancer confirmed by pathology who received surgical treatment in general surgery of Dujiangyan medical center were selected as the study object.The clinical and pathological data of all patients were collected.SIRI was calculated according to the absolute number of of peripheral blood neutrophils,lymphocytes and monocytes before operation.To draw the ROC curve of patients with SIRI to evaluate their postoperative survival status,and to determine the best boundary value by Youden index,and then divide the patients into high SIRI group and low SIRI group.The clinicopathological data of the two groups were compared.Kaplan Meier model was used to analyze the total survival time(OS) of the two groups.The independent risk factors of patients with OS were analyzed by multivariate Cox proportional risk regression model.
Results The best boundary value of SIRI is 1.398 by ROC curve.There were 81 cases in low SIRI group(SIRI <1.398) and 45 cases in high SIRI group(SIRI ≥1.398).There were significant differences in pathological differentiation,Nevin stage,infiltration depth,lymph node metastasis and operation mode between the two groups(P＜0.05).Kaplan Meier analysis showed that OS of high SIRI group was shorter than that in low SIRI group(P＜0.05).Multivariate Cox analysis showed that Nevin stage,lymph node metastasis,operation mode and preoperative SIRI were independent risks factor for OS in patients with gallbladder cancer(P＜0.05).
Conclusion The preoperative SIRI value is an independent risk factor for the prognosis of patients with gallbladder cancer,and it is expected to be an inflammatory marker to predict the postoperative survival status of patients.

Key words: systemic inflammation response index, gallbladder cancer, prognosis