Abstract: Objective To study Curative efficacy of Cerebrospinal fluid circulation reconstruction combined with decompression of bone flap in treatment of Traumatic brain injuryand its effectson intracranial pressure and Hypoxia-inducible factor-1(HIF-1),glial fibrinoacidic protein(GFAP),plasminogen activator(t-PA).
Methods 125 patients with craniocerebral injury who were treated in our hospital from June 2017 to June 2019 were selected and divided into the observation group(n=63) and the control group(n=62) by lottery.The control group was treated with decompression of bone flap,and the observation group was treated with cerebrospinal fluid circulation reconstruction on the basis of the control group.The clinical efficacy,changes in serum HIF-1,GFAP,t-PA,intracranial pressure,Glasgow outcome score(GOS),cerebral nerve function scale(CPC),European stroke score scale(ESS) and complications were compared between the two groups.
Results The total effective rate of the two groups was 92.06% and 72.58%,respectively(P<0.05).Before treatment,there was no significant difference in serum HIF-1,GFAP and t-PA levels between the two groups.After treatment,serum HIF-1,GFAP and t-PA levels in both groups were significantly improved,and the above indicators in the observation group were lower than those in the control group(P<0.05).Before treatment,there was no significant difference in intracranial pressure and GOS score between the two groups.After treatment,intracranial pressure and GOS scores in both groups were significantly improved,and intracranial pressure was lower than the control group,and GOS scores were higher than the control group(P<0.05).Before treatment,there was no significant difference in CPC and ESS scores between the two groups.After treatment,CPC and ESS scores in both groups were significantly improved,and CPC scores were lower than the control group,and ESS scores were higher than the control group(P<0.05).The total incidence of complications in the two groups was 9.52% and 32.26%,with statistically significant differences(P<0.05).
Conclusion Cerebrospinal fluid circulation reconstruction combined with craniocerebral flap decompression in patients with craniocerebral injury has a significant effect,which can effectively improve patients’ intracranial pressure and serum HIF-1,GFAP,t-PA levels,and fewer complications.

Key words: cerebrospinal fluid circulation reconstruction, decompression of bone flap, head injury, intracranial pressure, hypoxia-inducible factor-1, glial fibrillary acidic protein, plasminogen activator