Abstract: Objective To assess the predictive value of preoperative chest HRCT consolidation/tumor ratio (CTR) in patients with multiple ground-glass opacity (GGO).
Methods A total of 91 patients with N0 stage lung cancer were enrolled.The patients were divided into GGO group and solid nodule group by CTR=0.5.The difference of clinical and pathological features and 3-year recurrence survival rate (RFS) of the two groups were compared.
Results Among the 91 patients enrolled，35 (38.5%) had multiple GGO nodules.The maximum diameter of the GGO group was significantly smaller than that of the solid nodules group (10.2mm vs 21.6mm，P<0.05).COX multivariate regression analysis showed that tumors≥20mm (HR：1.22，P=0.043) and solid nodules (CTR≥0.5) were independent predictors of RFS.Kaplan-Meier survival curve analysis showed that the RFS of the GGO group was 91.4%，while the RFS of the solid nodule group was 75.0%.There was a significant difference between the two groups (P<0.05).
Conclusion The CTR value displayed by HRCT is an effective reference for follow-up and treatment of patients with multiple GGO.Surgical intervention is the preferred treatment when CTR is greater than 0.5.

Key words: lung cancer, ground-glass opacity, multifocal lesions, consolidation/tumor ratio, surgery