Abstract: Biliary malignancy refers to malignant tumors originating from the biliary epithelium, whose incidence and etiology vary geographically. The progress of comprehensive genomics has found abnormalities in different gene drivers. Advances in comprehensive genomics have revealed abnormalities in different gene drivers. A large number of studies have confirmed that cholangiocarcinoma not only has the characteristics of concealability, invasiveness and refractory, but also presents the multilevel heterogeneity between tumor and intratumor, which is affected by the interaction of different risk factors. Further understanding of its biological characteristics is of great significance for further research, more accurate diagnosis and more effective treatment. The purpose of this article was to review the biological characteristics of biliary tract cancer.

Key words: biliary tract cancer, biological characteristics