Abstract: Objective：To analyze the follow up effect of acute deep venous thrombosis（DVT）of the lower extremities through a contralateral femoral vein approach by percutaneous mechanical thrombolysis（PMT）combined with catheterdirected thrombolytic（CDT）therapy.Methods：From September 2016 to August 2017，45 patients were treated with PMT + CDT via contralateral approach，including 23 patients in the early thrombus group（0～7 days）and 22 patients in the late thrombus group（8～14 days）.The competent femoral valves，venous recanalization and the postthrombotic syndrome（PTS）rate in the two groups were analyzed and compared.Results：During the followup period of 20 months，37 patients with intact femoral vein valve function were observed，there was no statistical difference between the two groups；all iliac vein recanalization；the number of femoral popliteal recanalization（23 vs 17）and calf vein recanalization（22 vs 17）in the early thrombus group was higher than that in the late thrombus group.The incidence of post thrombosis syndrome（PTS）was 22%.and the early thrombus group was superior to the late thrombus group（10 vs.0）.Conclusion：The results of midterm followup confirmed that it is a feasible method to use contralateral approach to PMT + CDT for extensive acute DVT The incidence of PTS in early thrombus group was lower than that in late thrombus group.

Key words: contralateral femoral vein approach, percutaneous mechanical thrombectomy, catheterdirected thrombolysis, postthrombotic syndrome