Abstract: Objective To investigate the efficacy of endoscopic sphincterotomy（sEST）combined with balloon dilatation（EPBD）in the treatment of common bile duct stones combined with duodenal papillary diverticulum（JPDD）and serum bilirubin levels. Methods The clinical data of 87 patients with common bile duct stones and JPDD who underwent endoscopic retrograde cholangiopancreatography（ERCP）in our hospital from January 2015 to June 2017 were retrospectively analyzed.Among them，42 patients were treated with sEST combined with EPBD（experimental group）.45 patients were treated with sEST（control group）.The stone removal status and postoperative general indexes，the serum bilirubin levels [serum total bilirubin（TBil），direct bilirubin（DBil）] before surgery and 1 day after surgery of the two groups were compared. Results The success rate of one-time stone removal in the experimental group was 92.86%，which was significantly higher than 77.78% in the control group（P<0.05）.The rate of lithotripsy in the experimental group and the recurrence rate of one year after surgery were 4.76% and 2.38%，respectively，which were significantly lower than the control group's 20.00% and 15.56%（P<0.05）.TThe hospital stay in the experimental group was（7.85±2.17）d，which was shorter than that of the control group（9.72±2.85）d（P<0.05）.1 day after surgery，the serum levels of TBil and DBil in the experimental group were（156.06±51.27）μmol/L and（92.85±29.74）μmol/L，respectively，the serum TBil and DBil levels in the control group were（171.72±56.48）μmol/L and（105.42±34.81）μmol/L，respectively，which were significantly lower than those before surgery（P<0.05）.But there were no significant differences between the two groups（P>0.05）. Conclusion sEST combined with EPBD in the treatment of common bile duct stones combined with JPDD can significantly improve the success rate of one-time stone removal，reduce the use of lithotripsy and stone recurrence rate，patients recover faster，and can effectively improve their serum bilirubin levels.

Key words: common bile duct stones, duodenal papillary diverticulum, endoscopic sphincterotomy, balloon expansion