Abstract:

Objective Analysis of prognostic factors of invasive papillary carcinoma of the breast.

Methods To obtain female cases of invasive papillary carcinoma of the breast that have been registered in the Surveillance，Epidemiology，and End Results Program（SEER）database in the United States since 1990.According to the inclusion and exclusion criteria，the subjects in accordance with this study were selected.The clinicopathological distribution of the study data was described，and the Cox proportional hazard regression model was used to analyze the prognostic factors by univariate and multivariate analysis.

Results A total of 1413 cases of invasive papillary carcinoma of the breast were included in this study，of which 106 cases died specifically.Cox univariate analysis showed that tissue differentiation，estrogen receptor（ER），progesterone receptor（PR），T stage，N stage，M stage，operation and chemotherapy were related factors affecting prognosis（P<0.05）.Multivariate analysis showed that the higher the stage of lymph node metastasis，the higher the risk of poor prognosis.The risk of poor prognosis in stage T4 was 2.217times higher than that in stage T1（95%CI=1.056 to 4.655）.The risk of death in the PR negative group was 2.136 times higher than that in the PR positive group（95%CI=1.252 to 3.644），and the risk of death in breast conserving surgery was 0.086 times higher than that in the unoperated group（95%CI=0.029 to 0.252）.There was no significant difference in survival and prognosis between chemotherapy and chemotherapy（P=0.329，HR=0.787）.

Conclusion Patients with large tumor，locally advanced tumor，lymph node metastasis，negative PR and no treatment had a higher risk of tumor specific death.Early surgical intervention of invasive papillary carcinoma can slow down the progression of the disease and improve the prognosis，adjuvant radiotherapy and chemotherapy have no significant effect on the overall survival and prognosis of patients.

Key words: breast neoplasms, papillary carcinoma, monitor, epidemiology, SEER program