Abstract: Objective To carry out a Meta-analysis on the published data in order to evaluate the clinical efficacy of gemcitabine（GEM） combination with high intensity focused ultrasound（HIFU） in the treatment of advanced pancreatic carcinoma（PC） in China.Methods A comprehensive search was performed in WANFANG（1999～2018），CAJD（1995-2018），VIP（1989～2018） and CNKI（1994～2018） databases to collect the randomized controlled trials（RCTs） which to GEM combination HIFU with in the treatment of PC，and to analyze the RCTs in Meta-analysis method.Results 718 patients were analyzed in the 15 RCTs which met the inclusion criteria.The Meta-analysis results suggested that，compared with the simple HIFU or GEM treatment group，there were higher clinical effect rates， clinical benefit rates，half one year survival rates，one year survival rates and lower levels of CA19-9 in GEM combination with HIFU treatment group（P<0.05）.Conclusion The clinical efficacy of GEM combination with HIFU in the treatment of advanced pancreatic carcinoma is positive，and better than the simple GEM or HIFU treatment.

Key words: Pancreatic carcinoma, Gemcitabine, High intensity focused ultrasound, Clinical efficacy, Metaanalysis