Abstract: Objective To observe the clinical efficacy and safety of location-guided double-point and double-channel intracranial puncture in the treatment of hypertensive cerebral hemorrhage in basal ganglia.Methods 58 cases of hypertensive cerebral hemorrhage in basal ganglia were treated by location-guided  intracranial puncture and orientation.15 cases in the experimental group were treated with double-target and double-channel minimally invasive puncture and catheter drainage，while 43 cases in the control group were treated with single-channel puncture and catheter drainage.The clinical data and therapeutic effects of the two groups were summarized and analyzed.Results There was no significant difference in general data between the two groups（P>0.05）.51 patients were successfully punctured and the drainage tube was placed into the ideal target; there was no bleeding during puncture in both groups.The average indwelling time of the experimental group was（3.1±0.6）d，the clearance rate of hematoma after operation was 87.4%，the hospitalization time of NICU was（3.8±0.8）d，and the average hospitalization time was（10.6±1.6）d.The average indwelling time of the control group was（4.4±0.8）d，the clearance rate of hematoma after operation was 81.2%， the average hospitalization time of NICU was（5.5±1.3）d，and the average hospitalization time was（16.6±3.3）d.The average indwelling time，hospitalization time and NICU time of experimental group was significantly shorter than that of control group（P<0.05）.No intracranial infection occurred in both groups.Six months follow-up showed that the good prognosis rate of the experimental group was 66.67%，while that of the control group was 72.09%.There was no significant difference（P>0.05）.Conclusion Location-guided double-target and double-channel intracranial puncture is simple and feasible for the treatment of hypertensive intracerebral hemorrhage.The success rate of puncture is high.Compared with single-channel puncture，the risk of operation is not significantly increased，but the efficiency of hematoma drainage is higher，which can reduce NICU and total hospital stay，and is conducive to early rehabilitation of patients.

Key words: double target, double channel, intracranial puncture, hypertensive intracerebral hemorrhage, clinical efficacy