Abstract: Objective To discuss the diagnose and therapy of obstructive jaundice which could not be managed by surgery.Methods Five inpatient case reports of obstructive jaundice that could not be managed or failure to be managed just by surgery in recent one year.Results These 5 patients（0.9%） had average ALP value of （242.1±80.1）U/L，GGT value of （520.5±259.4）U/L，TBIL value of （216.1±97.9）μmol/L，and DBIL value of （120.5±64.7）μmol/L，which can be diagnosed of cholestasis.Among these patients，one patient diagnosed of hepatic hilar carcinoma who received left hemi-hepatectomy and choledochojejunostomy still had cholestasis after surgery.One patient who received common biliary operation for choledochal lithiasis had cholestasis after operation.The other 3 patients are relief from cholestasis after medication therapy.Conclusion The surgeons should be cautious of this kind of patients with obstructive jaundice originated from both intra- and extra-hepatic biliary obstruction.Multidisciplinary therapy（MDT） is an appropriate pattern for the patients with no obvious evidence of obstruction in bile duct on image.

Key words: obstructive jaundice, non-surgical disposal, clinical analysis