Abstract: Objective：To investigate the expression of interferoninduced transmembrane protein 3（IFITM3），Galectin7 and Galectin9 of midthoracic esophageal squamous cell carcinoma（ESCC）and relationship with lymphatic metastatic recurrence after modified Ivorlewis esophagectomy.Methods：91 patients with midthoracic ESCC underwent modified Ivorlewis esophagectomy with twofield lymphadenectomy were enrolled，the expression profile of IFITM3，Galectin7，Galectin9 protein of samples of the ESCC tissues and paracarcinoma tissues were detected by immunohistochemistry（IHC），the relationship of IFITM3，Galectin7，Galectin9 expression and lymphatic metastatic recurrence was analyzed.Results：The expression of IFITM3 and Galectin7 in samples of ESCC tissues was significantly higher than the paracarcinoma tissues，while the expression of Galectin9 was significantly lower than the paracarcinoma tissues，the  differences were statistically significant（P＜0.05）.The positive expression rate of IFITM3，Galectin7，Galectin9 in samples of ESCC tissues was 57.14%，65.93% and 60.44%，respectively；and the positive expression rate was 13.19%，5.49% and 89.01% in samples of paracarcinoma tissues，respectively.Tthe difference was statistically significant（P＜0.05）.With the increase of TNM stage，the positive expression rates of IFITM3 and Galectin7 were significantly increased（P＜0.05）.There was 37 patients（40.66%）with lymphatic metastatic recurrence within 3 years after surgery，the TNM stage，IFITM3 and Galectin7 overexpression，and Galectin9 underexpression were independent risk factors forymphatic metastatic recurrence（P＜0.05）.Conclusion：IFITM3，Galectin7 overexpression and Galectin9 underexpression might involve in occurrence and development of the midthoracic ESCC.It may be closely related to improved lymph node metastasis after Ivorlewis surgery.

Key words: esophageal squamous cell carcinoma, modified Ivorlewis esophagectomy, lymphatic metastatic recurrence, interferoninduced transmembrane protein 3, galectin