Abstract: Objective：To investigate the analysis of gastroesophageal reflux、nutrition and prognosis of proximal gastrectomy combined with pyloroplasty in the treatment of upper gastric cancer patients.〖WTHZ〗Methods：To screening 150 cases of upper gastric cancer patients as research subjects，it will be divided into study group with 75 cases and control group with 75 cases，patients in control group were given proximal gastrectomy and patients in study group were given proximal gastrectomy combined with pyloroplasty，then the two groups were compared in terms of clinical efficacy and so on.Results：The gastroesophageal reflux state of the study group was better than that of the control group（P<0.05）；The nutrition state in study group was better than the control group after operation（P<0.05）；The living quality in study group was better than the control group（P<0.05）；There was no significance in prognosis in 2 groups（P＞0.05）.Conclusion：The proximal gastrectomy combined with pyloroplasty in the treatment of upper gastric cancer patients is significant，it is worthy of popularization and application.

Key words: upper gastric cancer, proximal gastrectomy, pyloroplasty, gastroesophageal reflux, nutrition, prognosis