Abstract: Objective To investigate the effect of arthroscopic debridement combined with microfracture on joint function in the treatment of knee osteoarthritis（KOA）.Methods The clinical data of 180 cases of KOA treated were retrospectively analyzed，and patients were divided into two groups according to different treatment methods.88 patients in the control group received arthroscopic joint debridement，while 92 patients in observation group received arthroscopic debridement combined with microfracture.Then the knee joint function，pain degree，inflammatory factor levels，and clinical efficacy were compared between the two groups.Results The preoperative Lysholm score between the two groups had no difference（P>0.05），which was increased at the postoperative 1 month and 6 month，and the score was higher in the observation group（70.59±3.29，84.57±10.22）than in the control group（65.14±3.24，78.54±10.24）（P<0.05）.The preoperative VAS score had no difference（P>0.05），which was decreased at the postoperative 1 month and 6 month，and the score was lower in the observation group（21.88±5.54，12.57±8.55）than in the control group（30.19±5.59，24.50±8.59）（P<0.05）.The preoperative CRP and IL-6 levels had no difference（P>0.05），while the CRP was increased and the IL-6 was decreased at the postoperative 1mon and 6mon，moreover，both levels in the observation group[（13.69±6.18）mg/L，（20.31±10.42）ng/L] were higher than those in the control group[（23.51±6.71）mg/L，（26.51±10.41）ng/L]（P<0.05）.The clinical total effective rate in the observation group（97.83%）was significantly higher than that in the control group（89.78%，P<0.05）.Conclusion Compared with the arthroscopic joint debridement alone，the combination with the microfracture has a better effect on the improvement of knee joint function and decrease of pain degree for KOA patients.

Key words: arthroscopic debridement, microfracture, osteoarthritis of knee