Abstract:   Objective    To investigate the expression of FOXM1 and Ecadherin in breast cancer tissues and their relationship with clinicopathological parameters.Methods  The expression of FOXM1 and Ecadherin in breast cancer and surrounding normal tissues were detected by immunohistochemical method（IHC）.Then we analyzed the data with the SPSS statistical software.Results  The positive rate of FOXM1 protein was 48.5%（33/68）in 68 cases of invasive ductal carcinoma of breast，and the positive rate of Ecadherin protein was 41.2%（28/68）.The expression of FOXM1 protein in tumor tissues was higher than that in normal breast tissues.The expression of FOXM1 and Ecadherin was unrelated with age，location，histological grading and molecular typing.The expression rate of FOXM1 in axillary lymph node metastasis group was higher than that in nonlymph node metastasis group（P<0.05），and correlated with tumor size tumor TNM staging and estrogen receptor status（P<0.05）.The expression of Ecadherin protein was also correlated with lymph node metastasis and tumor TNM staging（P<0.05）.The expression of FOXM1 and Ecadherin protein was negatively correlated（r=-0.324，P<0.05）. Conclusion  FOXM1 and Ecadherin are important biomarkers of breast cancer.

Key words: breast cancer,  ,  , FOXM1, 〓 Ecadherin, tissue microarray