关键词: 8-羟基脱氧鸟苷, 连接蛋白-4, 原发性肝癌, 经导管肝动脉栓塞, 疗效

Abstract: Objective  To investigate the expression of 8-hydroxy deoxyguanosine (8-OHdG) and nectin-4 in the serum of primary liver cancer (PLC),and to evaluate the efficacy of transcatheter chemoembolization (TACE) for PLC.Methods  From January 2021 to June 2022,180 patients with primary liver cancer with TACE were studied.According to the efficacy of TACE patients,they were separated into a good group (n=137) and an adverse group (n=43).The general clinical data and the serum expression levels of 8-OHdG and nectin-4 were compared between the two groups;multivariate Logistic- regression was applied to analyze the influencing factors of postoperative efficacy in TACE for primary liver cancer;receiver operating characteristic was applied to analyze the value of serum 8-OHdG and nectin-4 levels in evaluating the efficacy of TACE for primary liver cancer.Results There were no significant differences in age,sex,BMI,Child-Pugh grade,tumor location,tumor number,tumor diameter,tumor contour,degree of differentiation,tumor envelope,vascular cancer thrombus,bile duct cancer thrombus and lymph node metastasis between the poor postoperative efficacy group and the good efficacy group after TACE for primary liver cancer (P>0.05).The expression levels of serum 8-OHdG and nectin-4 in the poor postoperative efficacy group after TACE for primary liver cancer were obviously higher than those in the good efficacy group (P<0.05).Multivariate -Logistic regression analysis showed that serum 8-OHdG,nectin-4,tumor diameter,TNM staging and Lymph node metastasis were all independent influencing factors for the postoperative efficacy of TACE in primary liver cancer (P<0.05).The AUC of the combined evaluation of serum 8-OHdG and nectin-4 for the postoperative efficacy of TACE in primary liver cancer was 0.930,with a sensitivity of 86.05% and a specificity of 94.16%,which was superior to their respective individual evaluations (Zcombination-8-OHdG=2.033,Z combinationnectin-4=3.221,P=0.042,0.001).Conclusion The serum levels of 8-OHdG and nectin-4 are obviously increased in the poor postoperative efficacy group after TACE for primary liver cancer.The combination of the two has a good evaluation effect on the postoperative efficacy of TACE for primary liver cancer.

Key words: 8-hydroxy deoxyguanosine, nectin-4, primary liver cancer, transcatheter hepatic chemoembolization, postoperative efficacy