临床外科杂志 ›› 2024, Vol. 32 ›› Issue (5): 476-479.doi: 10.3969/j.issn.1005-6483.2024.05.009

• 论著 • 上一篇    下一篇

超声造影体表定位联合纳米炭示踪行前哨淋巴结活检在cN0期浸润性乳腺癌病人中的应用分析

  

  1. 101300   北京市顺义区医院普外二科(杨丽,马强，张春霞)，超声科(郑永财，张辉)
  • 收稿日期:2023-05-06 修回日期:2023-05-06 接受日期:2023-05-06 出版日期:2024-05-25 发布日期:2024-05-25

Application of contrast-enhanced ultrasound body surface localization combined with nano carbon tracking for sentinel lymph node biopsy in cN0 invasive breast cancer patients

  1. Department of General Surgery,Beijing Shunyi Hospital,Beijing 101300,China
  • Received:2023-05-06 Revised:2023-05-06 Accepted:2023-05-06 Online:2024-05-25 Published:2024-05-25

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摘要： 目的  对比分析在cN0期浸润性乳腺癌(IBC)病人中应用超声造影(CEUS)体表定位联合纳米炭示踪行前哨淋巴结活检(SLNB)与单一染料法示踪行SLNB的手术耗时及其对前哨淋巴结(SLN)的检出率与检出数目，探讨CEUS体表定位联合纳米炭示踪行SLNB的可行性。方法 收集2018年1月1日~2023年4月30日于北京市顺义区医院诊治的199例cN0期IBC病人临床病理学资料，根据SLN示踪方法不同将所有病人分为染料法组100例和联合法组99例，染料法组应用纳米炭示踪行SLNB，联合法组术前应用CEUS对SLN行体表标记定位，术中应用纳米炭示踪行SLNB。结果 SLN检出率为96.48%(192/199)，染料法组检出率为95.00%，平均检出SLN(2.79±1.228)枚，联合法检出率为97.98%，平均检出SLN(3.32±1.469)枚，两组SLN的检出率比较差异无统计学意义(P＞0.05)，联合法组SLN的平均检出数目多于染料法组(P＜0.05)，但两组SLN检出数目分布比较差异无统计学意义(P＞0.05)，联合法组的SLNB手术耗时明显短于染料法[(13.83±4.58)min比(19.85±3.20)min，P＜0.05]。结论  联合法行SLNB可降低手术耗时并提高SLN的检出率及检出数目。

关键词: 浸润性乳腺癌, 超声造影, 前哨淋巴结活检, 纳米炭示踪, 联合法

Abstract: Objective To compare and analyze the operation time,detection rate and detection number of sentinel lymph node(SLN) who was using contrast-enhanced ultrasound(CEUS) body surface localization combined with nano carbon tracking and single dye method for sentinel lymph node biopsy(SLNB) in patients with cN0 invasive breast cancer(IBC).To explore the feasibility of CEUS body surface localization combined with nano carbon tracking for SLNB.Methods The clinicopathological data of 199 patients with cN0 IBC who were diagnosed and treated in Beijing Shunyi District Hospital from January 1st,2018 to April 30th,2023 were collected.We divided all patients into dye method group(100 cases) and combined method group(99 cases) according to SLN missing method.In dye method group,SLNB was performed with nano carbon tracer;In combined method group,SLN was marked and located by CEUS before surgery and SLNB was performed with nano carbon tracer during surgery.Results  The detection rate of SLN in this study was 96.48%(192/199).In the dye method group,the detection rate of SLN was 95.00% and the average detection number of SLN was(2.79±1.228).while in the combination method group,the detection rate was 97.98% and the average detection number of SLN was(3.32±1.469).There was no statistically significant difference in the detection rate of SLN between the two groups(P>0.05).The average detection number in combination method group was more than that in dye method group(P<0.05).However,there was no statistically significant difference in the distribution of SLN detection number between the two groups(P>0.05).The duration of SLNB surgery in the combination method group was significantly shorter than that in the dye method group[(13.83±4.58)minutes vs(19.85±3.20)minutes),P<0.05].Conclusion  Combined method for SLNB can reduce surgical time and increase the detection rate and number of SLN.

Key words: invasive breast cancer, contrast-enhanced ultrasound, sentinel lymph node biopsy, nano carbon, combined method

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