关键词: 叉头框蛋白M1； 程序性细胞死亡受体1配体； 胃癌； 临床病理特征； 预后

Abstract: Objective To analyze the expression of forkhead box protein M1(FOXM1) and programmed cell death receptor 1 ligand(PD-L1) in gastric cancer and their correlation with clinical prognosis.Methods From July 2017 to July 2019,124 patients with gastric cancer who received surgical treatment in our hospital were selected to have their gastric cancer tissues and corresponding adjacent tissues removed during the operation.FOXM1 and PD-L1 mRNA expression was detected by qRT-PCR;the expression of FOXM1 and PD-L1 proteins was detected by immunohistochemistry.The Kaplan-Meier survival curve was used to analyze the relationship between FOXM1 and PD-L1 and prognosis;COX regression was applied to analyze the risk factors affecting the prognosis of patients with gastric cancer.Results The expression levels of FOXM1 and PD-L1 mRNAs and the positive expression rates of proteins in gastric cancer tissue were obviously higher than those in adjacent tissues (P<0.05).The expression of FOXM1 and PD-L1 in gastric cancer was related to TNM stage and depth of invasion (P<0.05).According to Kaplan-Meier method,the 3-year survival rate of patients with FOXM1 and PD-L1 positive expression in gastric cancer tissue(39.47%) was lower than that of patients with negative expression(62.50%) (P<0.05).According to COX regression analysis,FOXM1 positive expression and PD-L1 positive expression were risk factors affecting the prognosis of gastric cancer patients (P<0.05).Conclusion The increased expression of FOXM1 and PD-L1 in gastric cancer is closely related to the clinicopathological characteristics and prognosis of patients,and is also a risk factor affecting the prognosis of patients with gastric cancer.

Key words: forkhead box protein M1; programmed cell death receptor 1 ligand; gastric cancer; clinicopathological characteristics; prognosis