关键词: 脑出血, 胞膜上嘌呤配体P2X门控离子通道型受体7, 脑水肿, 认知功能

Abstract: Objective To detect the level of purinergic receptor P2X,ligandgated ion channel 7 (P2X7R) and the degree of cerebral edema in patients with cerebral hemorrhage,and to analyze the correlation between the two and the cognitive function of patients with cerebral hemorrhage. Methods Prospectively,115 patients with cerebral hemorrhage admitted to our hospital from July 2019 to July 2021 were regarded as the study group.Another 90 healthy subjects who underwent physical examination were regarded as the healthy control group.The serum P2X7R level and the volume of cerebral edema were detected;Pearson correlation was used to analyze the correlation between P2X7R and brain edema volume;the patients were grouped into a no cognitive dysfunction group (78 cases) and a cognitive dysfunction group (37 cases) according to whether cognitive dysfunction occurred,multivariate Logistic regression was performed to analyze the cognitive function factors of patients with cerebral hemorrhage,receiver operating characteristic (ROC) curve of serum P2X7R level and brain edema volume in the assessment of cognitive function in patients with intracerebral hemorrhage was drawn. Results On the first day of onset,the serum P2X7R level in the study group were higher than those in the healthy control group (P<0.05),the serum P2X7R level and the volume of cerebral edema in patients with cerebral hemorrhage gradually increased during 1-5d,and reached the peak on the 5th day and then decreased (P<0.05);there were a positive correlation between serum P2X7R levels and brain edema volume in patients with cerebral hemorrhage on the 1st,3rd,5th,and 7th day of onset (r=0.712,0.583,0.589,0.472,P<0.05);the serum P2X7R level and brain edema volume in the Cognitive dysfunction group were higher than those in the no cognitive dysfunction group (P<0.05);serum P2X7R levels and brain edema volume are risk factors for cognitive dysfunction in patients with cerebral hemorrhage (P<0.05).The area under the curve of serum P2X7R level and cerebral edema volume alone and in combination was 0.763,0.750 and 0.829,respectively. Conclusion The level of serum P2X7R in patients with cerebral hemorrhage increases,and the volume of cerebral edema increases,and the two are positively correlated.Combined detection can predict the occurrence of cognitive dysfunction in patients.

Key words: cerebral hemorrhage, purinergic receptor P2X ligand-gated ion channel 7, cerebral edema, cognitive function