关键词: 吸烟, 淋巴结转移, 临床ⅠA期, 肺腺癌

Abstract: Objective   By comparing the lymph node metastasis of patients with different smoking status,the aim of current research was to investigate the effect of smoking on the LN metastasis rate of clinical stage ⅠA adenocarcinoma patients.  Methods   A total of 156 patients with clinical stage ⅠA lung adenocarcinoma were collected with different smoking stage from December 2013 to December 2017.All patients were grouped into three groups according to current smoking stage as former smoking group (FSG,n=47),smoking group (SG,n=45),and never smoking group (NSG,n=64).And compare the perioperative indexes,tumor size,degree of differentiation and lymph node metastasis rate,as well as prognosis data of different group patients.  Results   The median lymph node metastasis rates in SG, FSG and NSG groups were 24.49%, 22.77% and 10.19%, respectively.The maximum tumor diameters were 2.54cm, 2.62cm and 2.36cm, respectively.The rate of lymph node metastasis in SG and FSG group was higher than that in NSG group(P<0.05).Logistic regression analysis showed that smoking status and differentiation degree were independent influencing factors of lymph node metastasis.In terms of postoperative survival, patients with a history of smoking (SG and FSG) had a greater risk of lymph node metastasis, and smoking history and differentiation were independent prognostic factors(CI:1.297-6.829 and 1.054-1.280,respectively).Conclusion   Patients with a history of smoking have at greater risk of lymph node metastasis than those who never smoking,and smoking and the degree of differentiation are independent influencing factors of lymph node metastasis in patients.

Key words: somking, lymph node metastasis, clinical stage ⅠA, adenocarcinoma