关键词: 高龄, 结肠癌, CDH13, 临床特征, 预后

Abstract: Objective To investigate the relationship between CDH13 gene expression and clinicopathologic features and prognosis in elderly patients with colon cancer.Methods From January 2018 to May 2021,a total of 63 elderly patients were received surgical treatment for colon cancer in our research center,They were divided into two groups according to the expression of CDH13.Firstly,the expression of CDH13 in colon cancer was analyzed by bioinformatics method,Then,detected the expression of CDH13 by immunohistochemistry,The Chi-square test was used to analyze the relationship with clinicopathological parameters,and the survival curve was analyzed by Kaplan-Meier method.Results According to the TCGA data,the expression of CDH13 protein was decreased in colon cancer tissues (P=1.07e-15).The low expression of CDH13 in the two groups was statistically significant in lymph node metastasis (P<0.01),TNM stage (P=0.022) and Dukes stage (P<0.01).There was no significant difference in CDH13 expression when compared with clinical data such as gender ratio of patients,tumor location,surgical method,pathological type and whether chemotherapy was used.Kaplan-Meier survival curve analysis showed that the survival rate of patients with negative CDH13 expression was lower than that of patients with positive CDH13 expression,and the difference was statistically significant (χ2=4.927,P=0.026).Conclusion In elderly patients with colon cancer,CDH13 shows the function of tumor suppressor gene,and its expression level was related to TNM stage,Dukes stage and lymph node metastasis of colon cancer.The expression level of CDH13 reduced the long-term survival and affected the prognosis in elderly patients.

Key words: the elderly, colon cancer, CDH13, clinical features, prognosis