关键词: 非肌层浸润性膀胱癌, 经尿道膀胱肿瘤电切术, 二次电切术, 复发, 危险因素

Abstract: Objective To explore the risk factors of recurrence in patients with residual tumor after transurethral resection of bladder tumor (TURBT) for non muscle invasive bladder cancer.Methods The medical records of 100 patients with residual tumor after TURBT for non muscular invasive bladder cancer treated in our hospital from May 2020 to June 2021 were retrospectively analyzed.The patients were followed up for 12 months,and were divided into recurrence group(15 cases) and non recurrence group(85 cases).Multivariate logistic regression analysis was used to analyze the risk factors of recurrence in patients with non myometrial invasive bladder cancer after secondary resection.Nomogram nomogram model was established,and the working characteristic curve of subjects was drawn to analyze the predictive efficacy.Results 100 cases of non myometrial invasive bladder cancer were followed up for 12 months and 15 cases recurred.The 1-year recurrence rate was 15.00%.The proportion of multiple tumors,tumor stage T1 and low differentiation of tumor in the recurrent group before the first TURBT was higher than that in the non recurrent group,and the proportion of BCG perfusion after tumor pedicle and secondary resection was lower than that in the non recurrent group (P<0.05).The results of logistic regression analysis showed that multiple tumors,tumor stage T1 and low differentiation before the first TURBT were the risk factors for recurrence after the second resection (P<0.05).BCG infusion was the protective factor of recurrence after secondary resection (P<0.05).The area under the curve (AUC) of nomograph prediction model for predicting recurrence after secondary resection of non myometrial invasive bladder cancer was 0.759 (95%CI:0.641 ~ 0.827).Conclusion Multiple tumors before the first TURBT,tumor stage T1 and tumor low differentiation are the risk factors for recurrence after the second resection.BCG perfusion after the second resection is the protective factor for recurrence after the second resection.The establishment of nomogram model can be used to intuitively and comprehensively evaluate the risk of recurrence after the second resection.

Key words: non muscular invasive bladder cancer, transurethral resection of bladder tumor, secondary electrotomy, recurrence, risk factors