关键词: 胃癌, 维甲酸相关孤儿受体α, 微管相关蛋白轻链3, 远期预后, 相关性

Abstract: Objective To investigate the relationship between the expression of RORα and MAPLC3 in gastric cancer and long-term prognosis. Methods A total of 82 patients admitted to our hospital from January 2018 to June 2018 who were diagnosed with gastric cancer by pathological examination were selected as the research subjects.The expression of Retinoic acid-associated orphan receptor α(RORα) and microtubule associated protein light chain 3(MAPLC3) in gastric cancer tissues and adjacent tissues was detected by immunohistochemical staining,and their correlation with pathological factors was analyzed.Patients were divided into the death group(n=32) and the survival group(n=50),and the long-term prognosis of RORα and MAPLC3 expression in gastric cancer tissues of the two groups were analyzed and compared. Results The positive expression rates of RORα(42.68%) and MAPLC3(43.90%) in cancer tissues were significantly lower than those in adjacent tissues(84.15% and 91.46%),with statistical significance(P<0.05).The positive expressions of RORα and MAPLC3 in gastric cancer tissues had no significant differences with gender,age,tumor size,cancer cell type and pathological grade(P>0.05).The positive expression of RORα was related to T stage and lymphatic metastasis(P<0.05),and the positive expression of MAPLC3 was related to T stage,differentiation degree and lymphatic metastasis(P<0.05).Univariate analysis of long-term prognosis of gastric cancer patients showed that T stage,degree of differentiation,lymphatic metastasis,RORα expression,MAPLC3 expression and other factors were closely correlated with long-term prognosis of gastric cancer patients(P<0.05).Multivariate COX regression analysis showed that T stage(OR=1.779,95%CI:1.109~5.656) and differentiation degree(OR=1.621,95%CI:1.029~2.554),lymphatic metastasis(OR=1.876,1.020~3.451),RORα(OR=2.815,95%CI:1.401~5.656),MAPLC3(OR=3.080,95%CI:1.305~7.268) were independent risk factors for long-term prognosis of gastric cancer patients(P<0.05).The area under the curve for evaluating the prognosis and survival of gastric cancer patients was 0.67(95%CI:1.024~3.216),with a sensitivity of 72.34% and specificity of 64.58%.The area under the curve of MAPLC3 positive expression in gastric cancer tissues was 0.65(95%CI:1.023~2.547),with a sensitivity of 74.52% and specificity of 65.13%.Conclusion The expressions of RORα and MAPLC3 were lower in gastric cancer tissues.The positive expressions of RORα and MAPLC3 are independent risk factors for long-term prognosis of gastric cancer patients.

Key words: gastric cancer, retinoic acidrelated orphan receptor α, microtubuleassociated protein light chain 3, longterm prognosis, correlation