叉头框蛋白Q1和细胞周期蛋白D1在非小细胞肺癌组织中的表达与临床病理特征及预后的关系

doi:10.3969/j.issn.1005-6483.2022.05.015

摘要/Abstract

摘要： [摘要] 目的 探讨非小细胞肺癌(NSCLC)组织中叉头框蛋白Q1(FOXQ1)和细胞周期蛋白D1(CyclinD1)的表达水平与临床病理特征及预后的关系。方法选取2014年12月～2017年10月我院诊治的NSCLC病人癌组织标本196例及癌旁组织标本30例，采用免疫组化EnVisio法检测NSCLC组织及癌旁组织中FOXQ1和CyclinD1蛋白表达；分析FOXQ1、CyclinD1的表达与NSCLC病人临床病理参数的关系。采用Spearman相关分析FOXQ1与CyclinD1的相关性；采用Cox比例风险回归模型分析NSCLC病人预后的影响因素；采用Kaplan-Meier生存曲线分析FOXQ1、CyclinD表达与病人预后的关系。结果 NSCLC组织中FOXQ1、CyclinD1蛋白高表达率高于癌旁组织(P＜0.05)；NSCLC组织中FOXQ1、CyclinDl高表达与病理分化程度、临床分期、淋巴结转移相关(P＜0.05)；Spearman相关分析显示，NSCLC组织中FOXQ1表达与CyclinD1表达呈正相关(P＜0.05)；Cox回归分析显示，FOXQ1高表达、CyclinD1高表达、FOXQ1+CyclinD1高表达均是影响NSCLC病人无进展生存期(PFS)和总生存时间(OS)的独立危险因素（P＜0.05)；Kaplan-Meier分析显示，FOXQ1、CyclinDl两者高表达病人PFS和OS短于其他病人(P＜0.05)。结论 FOXQ1、CyclinD1蛋白在NSCLC组织中高表达，两者与疾病的发生、发展及预后密切相关，两者联合检测能更好地判断NSCLC病人的预后。

关键词: 非小细胞肺癌, 叉头框蛋白Q1, 细胞周期蛋白D1, 预后, 临床病理特征

Abstract: [Abstract] Objective To explore the expression levels of FOXQ1 and CyclinD1 in non-small cell lung cancer (NSCLC),and analyze their relationship with clinicopathological features and prognosis. Methods 196 cancer tissue samples and 30 adjacent tissue samples of NSCLC patients treated in our hospital from December 2014 to October 2017 were selected.The expressions of FOXQ1 and cyclinD1 protein in NSCLC tissues and adjacent tissues were detected by EnVisio immunohistochemistry.The expression levels of FOXQ1 and CyclinD1 in NSCLC and their relationship with clinicopathological parameters were analyzed.Spearman correlation was used to analyze the correlation between FOXQ1 and CyclinD1.Cox proportional hazards regression model was used to analyze the prognostic factors of NSCLC patients.Kaplan Meier survival curve was used to analyze the relationship between the expression of FOXQ1 and CyclinD and the prognosis. Results The high expression rates of FOXQ1 and cyclinD1 protein in NSCLC tissues were higher than those in paracancerous tissues (P<0.05).The high expression of FOXQ1 and CyclinDl in NSCLC was correlated with pathological differentiation,clinical stage and lymph node metastasis (P<0.05).Spearman correlation analysis showed that there was a positive correlation between foxq1 expression and CyclinD1 expression in NSCLC (P<0.05).Cox regression analysis showed that high expression of FOXQ1,CyclinD1 and FOXQ1+CyclinD1 were independent risk factors for progression free survival (PFS) and overall survival (OS) of NSCLC patients (P<0.05).Kaplan Meier analysis showed that the cumulative survival rates of PFS and OS in patients with high expression of FOXQ1 and CyclinDl were lower than those in other patients (P<0.05).The cumulative survival rates of PFS and OS in patients with high expression of FOXQ1 and CyclinDl were lower than those in patients with high expression of FOXQ1 and CyclinD1 alone (P<0.05).Conclusion FOXQ1 and CyclinD1 are highly expressed in NSCLC tissues,which are closely related to the occurrence,development and prognosis of the disease.FOXQ1 and cyclinD1 protein are positively correlated,the combined detection of both can better judge the prognosis of NSCLC patients.

Key words: non-small cell lung cancer, forkhead box Q1, CyclinD1, prognosis, clinical pathology features

叶彬向秋金文杰. 叉头框蛋白Q1和细胞周期蛋白D1在非小细胞肺癌组织中的表达与临床病理特征及预后的关系[J]. 临床外科杂志, 2022, 30(5): 453-458.

YE Bin, XIANG Qiu, JIN Wenjie. Expression of forkhead box Q1 and CyclinD1 in non-small cell lung cancer and their relationship with clinicopathological features and prognosis[J]. JOURNAL OF CLINICAL SURGERY, 2022, 30(5): 453-458.

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