关键词: 胃肠胰神经内分泌肿瘤, 临床及病理特征, 治疗, 预后

Abstract: Objective To analyze the characteristics of gastrointestinal pancreatic neuroendocrine neoplasm(GEP-NENs) and the risk factors that affect the prognosis of patients. Methods The clinical data and 36 month follow-up data of 108 patients with GEP-NENs who were hospitalized in the First Affiliated Hospital of Air Force Military Medical University from January 2009 to December 2016 were collected.Analyze its clinical characteristics,pathological characteristics and other indicators.Univariate and multivariate Cox regression models were used to study the prognostic factors affecting survival,and Kaplan-Meier method was used for survival analysis. Results The ratio of male to female was 1.16∶1,and the average age was (50.90±12.94) years.The predominant sites were pancreas,rectum,and stomach.The tumor diameter ranged from 0.2cm to 13.2cm,with a mean of (1.90±1.94)cm.Pathological classification:neuroendocrine tumor accounted for 88.9% and neuroendocrine carcinoma 11.1%.Pathological grade:G1 grade accounted for 52.8%,G2 grade accounted for 36.1%,and G3 grade accounted for 11.1%.Among them,95.4% of patients underwent surgical treatment,and 69.9% underwent radical surgical resection.The 3year overall survival rate was 87.1%.Univariate analysis of pathological type,grade,clinical stage,nonfunctional tumor,tumor diameter,Ki67 index,lymph node metastasis and distant metastasis are important factors affecting the prognosis of GEP-NENs patients(P＜0.05).Multivariate analysis showed that tumor size and lymph node metastasis were independent risk factors affecting the prognosis of patients with GEP-NENs.Conclusion The prognosis of patients with GEP-NENs is related to pathological type,grade,clinical stage,non-functional tumor,tumor diameter,Ki-67 index,lymph node metastasis and distant metastasis.Tumor size and lymph node metastasis are independent risk factors that affect the prognosis of patients.

Key words: gastrointestinal pancreatic neuroendocrine neoplasm, pathological feature, treatment, prognosis