关键词: 垂体瘤, 经鼻蝶手术, 低氧诱导因子-1α, 白细胞介素-6, 复发

Abstract: Objective To observe the value of serum hypoxia inducible factor-1 α(HIF-1 α) and interleukin-6(IL-6) in predicting the recurrence of elderly patients with pituitary adenomas after the treatment of transsphenoidal surgery. Methods 95 elderly patients with pituitary adenomas after the treatment of transsphenoidal surgery treated in our hospital from January 2015 to December 2017 were selected,all patients received surgical treatment in our hospital and received the results of 3 months of follow-up,the recurrence of patients was observed;the serum HIF-1 α and IL-6 levels were detected at admission,the value of the two in predicting the recurrence of elderly patients with pituitary adenomas after the treatment of transsphenoidal surgery was analyzed. Results Of 95 cases of elderly patients with pituitary adenomas after the treatment of transsphenoidal surgery through follow-up evaluation,18 cases had recurrence,the recurrence rate was 18.95%;the proportion of tumor invasion of patients in the recurrence group was higher than that in the non occurrence group,and the serum HIF-1 α and IL-6 levels were higher than those in the non occurrence group at admission(P<0.05);ROC curve was drawn,the results showed that the AUC of serum HIF-1 α and IL-6 alone or combined to predict the risk of recurrence in patients with pituitary adenoma surgery were all >0.80,which had certain predictive value.Conclusion  The overexpression of HIF-1 α and IL-6 at admission may be associated with recurrence in elderly patients with pituitary adenomas after the treatment of transsphenoidal surgery,which had certain value in predicting the risk of recurrence in patients.

Key words: pituitary adenomas, transsphenoidal surgery, hypoxia inducible factor-1 α, interleukin-6;recurrence