关键词: 乳腺癌, 个案管理, 内分泌辅助治疗, 服药依从性

Abstract: Objective  To investigate the current status of postoperative adjuvant endocrine therapy compliance in breast cancer patients attended the case management model,and to discuss the factors affecting their compliance.
Methods  From June 2013 to July 2017,this study enrolled 2072 breast cancer patients who received case management and accepted adjuvant endocrine therapy at Ruijin Hospital.Demographic characteristics and disease-related features were collected.Chi-square test was used to analyze the impact of these data on patients' compliance on the endocrine therapy designed by multi-disciplinary treatment(MDT).The statistically significant variables were further analyzed by logistic regression to fine out its corresponding impact level.
Results  The 5-year follow-up of adjuvant endocrine therapy,with a median time of (33.55±15.55)months,the compliance of 2 072 breast cancer patients was 99.61%,98.69%,97.38%,94.65% and 84.51%,respectively.The results of analysis showed that age,education,tumor stage(TNM stage) and the duration of endocrine therapy,all have statistically significant influence on therapy compliance(P<0.05).
Conclusion  The case management model is helpful to improve the adjuvant endocrine therapy compliance after breast cancer surgery.To further improve the therapy compliance,more attention should be paid to the patients older than 65,taking endocrine medicine over 3 years and early tumor stage.

Key words: breast cancer, case management, endocrine therapy, compliance