关键词: 颈动脉粥样硬化, 血压变化, 颈动脉内膜切除术, 重度颈动脉狭窄

Abstract: Objective To investigate the correlation between carotid endarterectomy(CEA) and blood pressure changes in patients with severe carotid stenosis.
Method 60 patients with severe carotid stenosis and hypertension who underwent CEA were selected as the experimental group;20 patients with severe carotid stenosis and hypertension who did not receive the CEA and receive conservative treatment were the control group.The DSA(digital subtraction angiography) confirmed the existence of unilateral carotid artery single severe stenosis and no other causes of hypertension.Based on the degree of carotid ar-tery stenosis,the experimental group was divided into the first group(70%～79% of unilateral carotid artery stenosis,n=20);the second group(80%～89% of unilateral carotid artery stenosis,n=20);the third group(90%～99% of unilateral carotid artery stenosis,n=20);the control group was the fourth group(70%～99% of unilateral carotid artery stenosis,n=20).Blood pressure was measured in 1 week before surgery，1 week after surgery，1 month after surgery，the 6 month after surgery in all four groups.Blood pressure changes were compared between the four groups.
Results  After the CEA,the blood pressure of the patients decreased significantly,the range of blood pressure decreased:the third group > the second group > the first group(P1∶2<0.05;P2∶3<0.01;P1∶3<0.001).
Conclusion CEA can significantly reduce the blood pressure in hypertensive patients with unilateral carotid artery single severe stenosis,the decrease of blood pressure is positively correlated with the degree of carotid artery stenosis,The more severe the degree of carotid stenosis,the greater the decrease of blood pressure.

Key words: carotid atherosclerosis, alternation of blood pressure, carotid endarterectomy, severe carotid stenosis