关键词: NOBp1, 乳腺癌, 总生存期, 预后

Abstract: Objective To investigate the expression of NOBp1 in breast cancer tissues and its correlation with clinicopathological factors and prognosis.
Methods A total of 90 patients with breast cancer admitted to our hospital from April 2013 to April 2014 were enrolled.Breast cancer tissues were taken and immunohistochemistry (IHC) was used to detect the expression of NOBp1 in cancer tissues.Followed up to October 2019,the correlation between NOBp1 expression level and clinical pathological factors and overall survival (OS) was analyzed.
Results Of the 90 patients,32 (35.6%) were positive for NOBp1 and 58 (64.4%) were negative for NOBp1.The expression of NOBp1 was correlated with lymph node metastasis status,tumor size and TNM stage (P<0.05),and there was no significant difference with age,menstrual status and molecular typing (P>0.05).As of October 2019,the patients were lost to follow-up in 5 patients.A total of 85 patients were followed up.The median follow-up time was 49 months,OS range:21～62 months,and 20 patients died during follow-up.Kaplan-Meier analysis showed that OS in the NOBp1 negative group was longer than the NOBp1 positive group (P=0.004).Univariate COX analysis showed that tumor size,lymph node status,TNM,molecular typing,NOBp1 expression were the prognostic factors affecting OS in breast cancer patients (P<0.05).Multivariate COX analysis showed lymph node status,TNM,Molecular typing and NOBp1 expression were independent prognostic factors affecting OS in breast cancer patients (P<0.05).
Conclusion Patients with elevated NOBp1 expression have shorter OS and are risk factors for breast cancer prognosis.Patients with elevated NOBp1 expression have poor prognosis.

Key words: NOBp1, breast cancer, overall survival, prognosis