关键词: 肾移植, 〓 他汀类药物, 〓 横纹肌溶解症, 〓 急性肾损伤

Abstract: Objective〖WTBZ〗〓To investigate diagnosis and treatment methods of the statininduced rhabdomyolysis in renal transplant recipients.〖WTHZ〗Methods〖WTBZ〗〓A retrospective study was performed on the clinical date of a case of atorvastatininduced rhabdomyolysis and acute renal failure triggered by addition of cyclosporine A（CsA）to a kidney transplant recipient.Given his diabetes，the recipient received CsAcontaining immunosuppressive regimens，and he had been continually treated with atorvastatin（20 mg/d）owing to hyperlipidemia for the preceding 2 years.〖WTHZ〗Results〖WTBZ〗〓The patient got a delayed graft function until the 22nd day after the operation.Then the patient developed severe rhabdomyolysis on the 29th day after the surgery，followed by acute kidney failure in 33 days.Finally，he showed gradual recovery in renal function and overall clinical status on the 75th day after the surgery.The serum creatinine remained stable at about 80 μmol/L at the time of the followup to March 29，2018.〖WTHZ〗Conclusion〖WTBZ〗〓It is advisable to start with small dosage of lipidlowering agent and pay more attention to the possible muscle toxicity when the CsAtreated renal transplant recipient took statins metabolized by CYP3A4 for hyperlipidemia.