临床外科杂志 ›› 2018, Vol. 26 ›› Issue (10): 744-746.doi: 10.3969/j.issn.10056483.2018.10.008

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沉默信息调节因子7在胃癌组织的表达及其与胃癌临床病理的关系

  

  1. 430022 武汉市第一医院乳腺甲状腺外科(林海鹏);华中科技大学同济医学院附属协和医院胃肠外科(卢晓明、牛彦锋),放射科(王莉霞)
  • 收稿日期:2018-01-16 出版日期:2018-10-20 发布日期:2018-10-20
  • 通讯作者: 牛彦锋,Email:nyfeng752003@126.com
  • 基金资助:
    湖北省自然科学基金面上项目(2017CFB644);湖北省自然科学基金面上项目(2017CFB708);武汉市科学技术计划项目(2014062801011269)

Expression of silent information regulator 7 in gastric cancer and clinical significance

  1. Department of Breast and Thyroid Surgery,Wuhan first hospital,Wuhan 430022,China
  • Received:2018-01-16 Online:2018-10-20 Published:2018-10-20

摘要: 目的   观察沉默信息调节因子7(SIRT7)在胃癌组织中的表达,分析其与胃癌临床病理特征的关系。方法 收集195例胃癌病人的癌组织和癌旁正常组织, Western blot检测SIRT7在胃癌及癌旁组织中的表达水平,免疫组织化学方法检测不同病理特征的胃癌组织和癌旁组织中SIRT7的表达。结果 胃癌组织中SIRT7阳性率(65.64%)明显高于癌旁正常组织的阳性率(19.49%),差异有统计学意义(P<0.05)。SIRT7在胃癌组织中的表达与病人年龄、性别及肿瘤大小无明显相关(P>0.05),而与胃癌淋巴结转移、浸润深度、TNM分期明显相关(P<0.05)。结论 SIRT7在胃癌组织中的表达高于癌旁正常组织,且与胃癌淋巴结转移、浸润深度、TNM分期密切相关,表明SIRT7在胃癌的侵袭过程中发挥重要作用。

Abstract: Objective  To study the expression level of SIRT7 in the gastric cancer,analyze the correlation between SIRT7 and clinicopathological characteristics of gastric cancer,and explore possible mechanisms of the involvement of SIRT7 in the occurrence and development of gastric cancer.Methods 195 cases of gastric carcinoma and paracarcinoma tissues were collected.Western blot was used to detect the protein expression of SIRT7 in gastric carcinoma and adjacent tissues.Immunohistochemistry was operated to detect the expression of SIRT7 and the correlation between SIRT7 and clinicopathological characteristics of gastric cancer.Results The positive rate of SIRT7 expression in gastric cancer(65.64%)was significantly higher than in the adjacent tissues(19.49%)(P<0.05).The expression of SIRT7 was not related to age,gender and the size of tumor(P>0.05),but related to lymph node metastasis,depth of invasion and TNM staging(P<0.05).Conclusion  The expression of SIRT7 in gastric cancer is higher than in normal tissues,and is correlated with lymph node metastasis,depth of invasion and TNM staging,suggesting their roles in the gastric cancer.

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