关键词: 原发性肝癌, 介入治疗, 肝纤维化, 骨桥蛋白, 血管生成素样蛋白8

Abstract: Objective  To investigate the correlation between serum osteoblastin (OPN) and angiopoietin-like protein 8 (ANGPTL8) levels and hepatic fibrosis (HF) after interventional therapy-transcatheter arterial chemoembolisation (TACE) in patients with primary hepatocellular carcinoma (PHC). Methods 166 patients with PHC admitted between March 2021 and June 2023 were selected and divided into 92 cases with HF (observation group) and 74 cases without HF (control group) according to whether or not HF occurred after interventional therapy; enzyme-linked immunosorbent assay (ELISA) was used to determine the serum OPN and ANGPTL8 levels and to analyse the predictive value of the OPN and ANGPTL8 levels on HF.Pearson correlation was used to analyze the correlation between OPN and ANGPTL8 levels and biochemical indexes.The factors influencing the occurrence of HF were analyzed by multi-factor Logistics- regression. ROC curve was used to analyze the predictive value of OPN and ANGPTL8 for HF. Results  Serum OPN [(74.56±11.56) ng/ml], ANGPTL [(42.78±5.23) ng/ml], ALT [(62.24±9.56) U/L], AST [(42.88±8.23) U/L], HA [(252.98±52.44) ng/L], LN [(152.64±26.45) ng/L], PCⅢ[(16.54±3.46)ng/L] and Ⅳ-C[(152.78±21.23)ng/L] in observation group were significantly higher than the control group[(57.89±9.68)ng/ml,(35.46±4.78)ng/ml,(49.46±7.46)U/L,(31.48±7.26)U/L,(192.56±23.88)ng/L,(124.48±11.23)ng/L,(11.26±2.23)ng/L and (126.45±18.56)ng/L].The differences between the two groups were statistically significant (P<0.05). The AUC of serum OPN, ANGPTL8 and the combination of the two in predicting the occurrence of HF were 0.914, 0.920 and 0.978, respectively, and the AUC of OPN combined with ANGPTL8 in predicting the occurrence of HF was higher than the AUC of the two separately (P<0.05). Conclusion  The levels of serum OPN and ANGPTL8 of patients with PHC are closely associated with the occurrence of HF, and the two are HF occurrence influencing factors and can be used as indicators to predict the occurrence of HF.

Key words: primary hepatic carcinoma, interventional therapy, liver fibrosis, osteopontin, angiopoietin like protein 8