关键词: 黏膜下膀胱肿瘤整块剜切术, 非肌层浸润性膀胱癌, 经尿道膀胱肿瘤电切术, 术中出血量, 氧化应激

Abstract: Objective To investigate the effect of transurethral plasma resectoscope retrograde submucosal enucleation of bladder tumor(ERBT) on blood loss and oxidative stress in patients with non myometrial invasive bladder cancer(NMIBC).Methods92 patients with NMIBC who underwent surgery in our hospital from January 2019 to January 2021 were selected as the research object.The data of the patients were analyzed retrospectively.According to the operation method,they were divided into transurethral resection of bladder tumor(TURBT) group(n=53) and erbt group(n=39).The changes of operation related indexes,operation complications,micturition function and blood oxidative stress indexes before and after operation were recorded and compared between the two groups.〖WTHZ〗Results〓〖WTBZ〗There was no significant difference in the operation time and catheter retention time between the two groups(P>0.05).The amount of intraoperative bleeding in erbt group was significantly less than that in TURBT group,and the bladder flushing time and hospital stay were significantly shorter than that in TURBT group(P<0.05).The incidence of obturator nerve reflex in erbt group was significantly lower than that in TURBT group(P<0.05),and the incidence of bladder perforation and urinary tract infection were also lower than that in TURBT group,but there was no significant difference(P>0.05).The maximum urinary flow rate(Qmax) and maximum detrusor pressure(MDP) in erbt group were significantly higher than those in TURBT group,and the residual urine volume(PVR) was significantly lower than that in TURBT group(P<0.05).7 days after operation,serum glutathione peroxidase(GSH PX),superoxide dismutase(SOD) and total antioxidant activity(AOA) in erbt group were significantly higher than those in TURBT group,while serum malondialdehyde(MDA) was significantly lower than that in TURBT group(P<0.05).Conclusion Transurethral plasma erbt can significantly reduce the amount of intraoperative bleeding in patients with NMIBC,shorten the time of intraoperative bladder flushing,effectively alleviate the body's oxidative stress response caused by surgery,and reduce the incidence of obturator nerve reflex,which is conducive to the postoperative prognosis of patients.

Key words: enucleation of bladder tumor, non myometrial invasive bladder cancer, transurethral resection of bladder tumor, intraoperative blood loss, oxidative stress