转钴胺1在结直肠癌及其肺转移组织中的表达及临床意义

doi:10.3969/j.issn.1005-6483.2022.01.016

摘要/Abstract

摘要： 目的探讨转钴胺1(transcobalamin 1,TCN1)在结直肠癌(colorectal cancer,CRC)及其肺转移组织中的表达状况及其临床意义。
方法收集2009年5月～2019年1月我院收治的42例CRC肺转移病人的结肠镜活检组织、CRC及癌旁正常黏膜组织、肺转移癌组织、正常肺组织蜡块病理标本，用免疫组化法检测以上组织中TCN1表达状况，分析TCN1表达水平与CRC病人临床特点及与新辅助化疗的关系。
结果 CRC及其肺转移癌组织中TCN1表达水平高于癌旁结直肠黏膜组织及正常肺组织(P<0.01)。CRC肺转移癌组织中TCN1表达水平与CRC组织中TCN1表达水平相似，两组之间TCN1表达强弱比较，差异无统计学意义(P=0.588)。肠镜活检CRC组织中TCN1表达水平与手术切除CRC组织中表达水平一致(P<0.01)，接受新辅助化疗后CRC组织中TCN1表达水平降低。
结论 TCN1在CRC及CRC肺转移癌组织中高表达，在肠镜活检组织中与手术切除组织中表达水平一致，新辅助化疗可以降低CRC组织中的TCN1表达水平，有望作为预测CRC肺转移和化疗敏感性的生物学标志物。

关键词: 转钴胺素1, 结直肠癌, 肺转移瘤, 新辅助化疗

Abstract: Objective To discuss the expression level of Transcobalamin I(TCN1) in colorectal cancer(CRC) and lung metastasis tumors and its clinical significance.
Methods A total of 42 cases of CRC patients with lung metastasis were collected in the Fourth Hospital of Hebei Medical University form May,2009 to January,2019.The expression level of TCN1 in the tissues,including CRC tissues,adjacent normal colonrectal mucosa tissues,lung metastastatic tissues and normal lung tissues,was detected by immunohistochemistry(IHC),and the relationships between expression level of TCN1 and the clinical characteristics of CRC were analyzed.
Results TCN1 was highly expressed in CRC and its lung metastasis tissues than in the adjacent colorectal mucosa and normal lung tissues(P<0.01).There was a similar expression levels between the expression level of TCN1 in CRC and its lung metastasis tissues and CRC and normal lung tissues(P=0.588).The expression level of TCN1 in CRC tissues by colonoscopy was consistent with that in surgically resected CRC tissues(P<0.01).TCN1 expression level in CRC tissue decreased after neoadjuvant chemotherapy.
Conclusion TCN1 is highly expressed in CRC and CRC lung metastasis tissues,neoadjuvant chemotherapy can reduce the expression level of TCN1 in CRC tissues.TCN1 is expected to be a biomarker for predicting lung metastasis and chemosensitivity of CRC.

Key words: transcobalamin 1, colonrectal cancer, metastatic tumor of lung, neoadjuvant chemotherapy

刘永斌王成刘延杰刘芳岳萌吕菲刘广杰王贵英. 转钴胺1在结直肠癌及其肺转移组织中的表达及临床意义[J]. 临床外科杂志, 2022, 30(1): 54-57.

LIU Yongbin, WANG Cheng, LIU Yanjie, et al.. Expression and clinical significance of transcobalamin 1 in colorectal cancer and its lung metastasis tissues[J]. JOURNAL OF CLINICAL SURGERY, 2022, 30(1): 54-57.

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