关键词: 胃癌, 血小板/淋巴细胞比值, 预后

Abstract: Objective To investigate the relationship between preoperative platelet/lymphocyte ratio(PLR) and prognosis in patients with gastric cancer,and analyze factors affecting the prognosis of patients.
Methods The clinical and prognostic data of 267 patients with gastric cancer who were admitted to the Secend Hospital of Anhui Medical University form January 2013 to December 2015 were retrospective analyzed.The survival curve was drawn by Kaplan-Meier method.The survival analysis and univariate analysis were done using the Log-rank test,and multivariate analysis was done using the COX proportional hazards model.
Resrults The mean preoperative PLR in the 267 patients was 177.2±109.9.According to the preoperative PLR,the patients were divided into the low PLR group(PLR<177.2,n=167) and the high PLR group(PLR≥177.2,n=100).The median survival time and 5-year cumulative survival rate of the high PLR group and the low PLR group were 17 months and 22.9%,33 months and 41.20%,respectively,with a significant difference in the survival of patients in low and high PLR groups(P<0.05).The results of univariate analysis showed that age,tumour size,Borrmann type,T stage,N stage,TNM stage,carcinoembryonic antigen value and PLR were factors affecting the prognosis of patients with gastric cancer(P<0.05).The results of multivariate analysis showed that age more than 65 years,tumour size more than 5cm,stage Ⅲ and high PLR were independent risk factors affecting the prognosis of patients with gastric cancer(P<0.05).
Conclusion High preoperative PLR corresponded to poor prognosis of patients with gastric cancer.

Key words: gastric cancer, platelet/lymphocyte ratio, prognosis