关键词: 结直肠癌, 无进展生存, 癌症特异性生存, γ-谷氨酰转肽酶, 乳酸脱氢酶, 碱性磷酸酶

Abstract: Objective To estimate the clinical practicability and values of serum enzymology related indicators by evaluating the predictive performance of these indicators on the prognosis of colorectal cancer.Methods By referring to the medical records，the clinicopathological data of 509 colorectal cancer patients，and serum enzymatic indexes before and 1 month after surgery were collected.Cox proportional risk regression was used to analyze the associations between the serum enzymatic indicators and progression free survival（PFS）and cancer-specific survival（CSS）of colorectal cancer patients by calculating Hazard Ratio（HR）and 95% Confidence interval（CI）.Results Preoperative and postoperative high levels of alkaline phosphatase（ALP），gamma-glutamyl transpeptidase（GGT）and lactate dehydrogenase（LDH）were associated with PFS，with HRs（95% CI）of 1.41（1.02～1.92），1.45（1.05～2.02）and 3.15（2.04～4.87）for preoperative indicators，respectively，and 1.33（1.14～2.78），1.78（1.10～2.01）and 1.72（1.04～2.84）for postoperative indicators，respectively.Preoperative alanine aminotransferase（ALT），aspartate aminotransferase（AST），ALP，GGT and LDH were independent prognostic factors for CSS，with HRs（95% CIs）of 1.73（1.10～2.72），1.78（1.11～2.86），1.99（1.26～3.16），2.47（1.55～3.93）and 4.24（2.56～7.04），respectively.Patients with higher postoperative ALP，GGT and LDH levels had shorter CSS，with HRs（95% CIs）of 2.25（1.24～4.10），2.14（1.02～4.52）and 2.88（1.49～5.68），respectively.Conclusion GGT，LDH and ALP can be used as prognostic markers of colorectal cancer.

Key words: colorectal cancer, progression-free survival, cancer-specific survival, gamma-glutamyl transpeptidase, lactate dehydrogenase, alkaline phosphatase