趋化因子配体12／趋化因子受体7在胃癌中的表达及其与临床病理特征的相关性

doi:10.3969/j.issn.1005-6483.2019.10.013

摘要/Abstract

摘要： 目的研究趋化因子配体12（chemokine ligand 12，CXCL12）／趋化因子受体7（chemokine receptor 7，CXCR7）在胃癌中的表达及其与临床病理特征的相关性。方法选取2016年12月～2017年12月我院行胃癌根治手术病人的癌组织及癌旁正常组织石蜡标本180例，采用免疫组化染色法测定胃癌组织及癌旁正常组织中CXCL12、CXCR7表达水平，分析CXCL12、CXCR7在胃癌组织中表达的相关性，分析CXCL12/CXCR7表达与胃癌临床病理学特征的关系。结果 CXCL12在胃癌组织的阳性表达率为62.22%，癌旁正常组织为35.56%，两组比较差异具有统计学意义（P<0.05）；CXCR7在胃癌组织的阳性表达率为68.89%，癌旁正常组织为44.44%，两组比较差异有统计学意义（P<0.05）；CXCL12、CXCR7在胃癌组织中表达呈正相关（P<0.05）；肿瘤直径、浸润程度、淋巴结转移情况、临床分期不同的胃癌病人癌组织中CXCL12+CXCR7+表达有显著差异（P<0.05）。不同CXCL12/CXCR7病人的1年生存率差异有统计学意义（P＜0.05），CXCL12阳性CXCR7阳性病人的1年生存率较低（P＜0.05）。结论 CXCL12、CXCR7在胃癌病人中呈高表达，CXCL12/CXCR7生物学轴与胃癌病人的肿瘤直径、浸润程度、淋巴结转移、临床分期显著相关。

关键词: 胃癌, 趋化因子配体12, 趋化因子受体7, 临床病理特征

Abstract: Objective To investigate the expression of chemokine ligand 12/chemokine receptor type 7（CXCL12/CXCR7）in gastric cancer and its correlation with clinicopathological features.Methods In this study，the expressions of CXCL12 and CXCR7 in gastric cancer tissues and adjacent normal tissues of 180 patients undergoing radical gastrectomy in our hospital from December 2016 to December 2017 were determined by immunohistochemical staining.Then the correlation to the clinicopathological features was also analyzed.Results The positive expression rate of CXCL12 in gastric cancer tissues[62.22%（112/180）] was significantly higher than that in adjacent normal tissues[35.56%（64/180）]（P<0.05）.The positive expression rate of CXCR7 in gastric cancer tissues[68.89%（124/180）] was significantly higher than that in adjacent normal tissues[44.44%（80/180）]（P<0.05）.CXCL12 and CXCR7 were positively correlated in gastric cancer tissues（P<0.05）；The expression levels of CXCL12+CXCR7+ among gastric cancer patients with different tumor diameter，degree of invasion，lymph node metastasis and clinical stage showed statistic difference（P<0.05）.The 1-year survival rate of patients with different CXCL12/CXCR7 was significantly different（P<0.05）.The 1-year survival rate of patients with CXCL12+CXCR7+was lower（P<0.05）.Conclusion CXCL12 and CXCR7 are highly expressed in gastric cancer patients，and the biological axis of CXCL12/CXCR7 is significantly correlated with gastric cancer tumor diameter，invasion degree，lymph node metastasis and clinical stage.

Key words: gastric cancer, chemokine ligand 12, chemokine receptor 7, clinicopathological characteristics

陈虹, 丁杰, 王萌, 刘雅炜, 管文贤. 趋化因子配体12／趋化因子受体7在胃癌中的表达及其与临床病理特征的相关性[J]. 临床外科杂志, 2019, 27(10): 866-869.

CHEN Hong, DING Jie, WANG Meng, et al.. Expression of chemokine ligand 12/chemokine receptor 7 in gastric cancer and its correlation with clinicopathological features[J]. JOURNAL OF CLINICAL SURGERY, 2019, 27(10): 866-869.

参考文献

相关文章 15

[1]	李子禹, 薛侃. 胃癌外科诊疗有感[J]. 临床外科杂志, 2019, 27(5): 361-362.
[2]	郑勇斌. 胃癌根治术中脾门淋巴结清扫的热点和争议[J]. 临床外科杂志, 2019, 27(5): 373-375.
[3]	郭伍斌, 马新, 黎晖. Fbxw7过表达促进mTOR降解并抑制胃癌细胞迁移的研究[J]. 临床外科杂志, 2019, 27(5): 379-382.
[4]	王家欢, 汪洋. 近端胃切除加幽门成形术对近端胃癌病人胃食管反流及营养的影响[J]. 临床外科杂志, 2019, 27(5): 387-389.
[5]	王剑屏, 商建, 刘岚, 王晓月, 李自昂, 王倩, 林军. Ki-67标记指数评价胃肠道间质瘤危险度分级探讨[J]. 临床外科杂志, 2019, 27(5): 383-386.
[6]	李欣龙, 顾立虎, 祝和攀, 潘军海, 陈玉萍. 加速康复外科理念在腹腔镜胃癌根治术中的应用[J]. 临床外科杂志, 2019, 27(5): 404-407.
[7]	周东, 何艳平, 李恒平, 黄卫东. 不同腹腔镜胃癌根治术对原发性胃癌病人胃肠动力、炎性应激及预后的影响分析[J]. 临床外科杂志, 2019, 27(5): 436-438.
[8]	田江, 葛亮, 戴豫新, 黎培员, 田书信. 内镜与外科手术治疗符合内镜黏膜下剥离术扩大适应证的老年单发早期胃癌的疗效对比[J]. 临床外科杂志, 2019, 27(11): 961-964.
[9]	梁寒. 中国残胃癌定义的外科专家共识意见（2018年版）解读[J]. 临床外科杂志, 2019, 27(1): 29-31.
[10]	袁野曹钧蔡逊. 短疗程糖皮质激素对原发性胃癌病人术后并发症及炎性细胞因子的影响[J]. 临床外科杂志, 2018, 26(11): 852-854.
[11]	姬乐刘涛白浪高永涛. 腹腔镜远端胃癌D2根治术对老年进展期胃癌病人CEA、DDC及血清HIF1α、MACC1的影响[J]. 临床外科杂志, 2018, 26(10): 739-743.
[12]	林海鹏卢晓明王莉霞牛彦锋. 沉默信息调节因子7在胃癌组织的表达及其与胃癌临床病理的关系[J]. 临床外科杂志, 2018, 26(10): 744-746.
[13]	吴永丰刘兴洲柳东陶庆松. 胃癌全胃切除术中行调节型双通道消化道重建对患者胆囊收缩功能及营养状况的影响[J]. 临床外科杂志, 2018, 26(10): 767-770.
[14]	秦敬. 胃癌合并原发性腹茧症一例[J]. 临床外科杂志, 2018, 26(10): 800-800.
[15]	王伟王代宏尹小平等. 胃癌组织IFITM1表达与临床及预后价值的探讨 [J]. 临床外科杂志, 2013, 21(5): 346-349.

Metrics

Viewed

Full text

Abstract

Cited

Shared

Discussed