Abstract:   [Abstract]  Objective   To investigate the efficacy of laparoscopic surgery in the treatment of acute cholecystitis and its effects on intercellular adhesion molecule1(ICAM1),proteins of the matrix metalloproteinase9(MMP9)and vascular endothelial growth factor(VEGF).Methods  100 patients with acute cholecystitis admitted to our hospital were divide them into two group with the random number table.50 cases were treated with laparoscopic cholecystectomy(group LC)and other 50 cases were treated with open cholecystectomy(group OC).At the same time,50 healthy subjects were selected as the control group.The curative effect,postoperative complications,serum ICAM1,MMP9 and VEGF concentrations in patients before and after surgery were observed. Results The operation time(48.34±10.50)min,intraoperative blood loss(51.36±7.42)ml,intestinal function recovery time(43.47±5.62)h and postoperative hospital stay(4.89±1.06)d were significantly shorter in the LC group than in the OC group[（73.91±11.68）min,（92.45±8.63）ml,（71.59±8.15）h and（9.12±1.45）d,P<0.05].The number of complications such as incision infection in 2 cases,0 cases of bile duct injury,1 case of ascites and 1 case of aspiration pneumonia in the LC group were significantly lower than those in the OC group(P<0.05).The serum levels of ICAM1 was(0.34±0.04)ng/mL,MMP9 was(12.08±1.74)ng/mL and VEGF was(164.52±15.74)pg/mL were significantly lower in the LC group than in the OC group[（0.40±0.03）ng/ml,（15.65±1.68)ng/ml and（197.86±15.64）pg/ml,P<0.05.Conclusion Laparoscopic surgery has a good clinical efficacy in the treatment of acute cholecystitis,and the incidence of postoperative complications is low.It can effectively improve the expression of ICAM1,MMP9 and VEGF in patients.
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