关键词: 局部进展期直肠癌, 新辅助放化疗, 病理完全缓解

Abstract: [Abstract]objective  Retrospective analysis of prognosis，recurrence and metastasis after treatment of significance and operation assisted radical postoperative stage pT1 squamous cell carcinoma of thoracic esophagus.Methods  131 cases of stage pT1 thoracic esophageal cancer which were diagnosized and treated with radical resection.SPSS 21.0 statistical software was used to statistical analysis.Results The end of followup was January，2018.During the followup period，34 （25.95%）patients died，27 died from the tumor itself，and 7 died from other causes.28 cases （21.4%）was local recurrence and/or distant metastasis，which including 15 cases （11.45%）of local regional recurrence，9 cases （6.87%）of distant metastasis and 4 cases （3.05%）of local regional recurrence combination of distant metastasis.The 1，3，5year overall survival（OS）rates were 96.9％，90.8％，86.3％，respectively；the 1，3，5year rates of progression free survival（PFS）were 80.2％，71.0％，69.5％，respectively.Univariate analysis showed lymphatic metastasis，vascular invasion，depth of invasion and drinking were the independent risk factors for local recurrence and （or）distant metastasis in patients with pT1 esophageal squamous carcinoma（P<0.05），with multivariate analysis，vascular invasion and drinking were the independent risk factors for local recurrence and （or）distant metastasis in patients with pT1 esophageal squamous carcinoma（P<0.05）.The KaplanMeier method remind lymphatic metastasis，vascular invasion，drinking and tumor size（＞2.0cm）were the independent risk factors for OS and PFS（P<0.05）；COX’S regression model remind vascular invasion，drinking，tumor size（＞2.0cm），differentiation degree and tumor length were the 〖LM〗independent risk factors for OS and PFS（P<0.05）.Conclusion For patients of stage pT1 squamous cell carcinoma of thoracic esophagus after radical resection，there were still 21.4% of patients with local recurrence and/or distant metastasis.Postoperative pathology indicated that the tumor length >2.0cm，lymph node metastasis，infiltration depth of the submucosa，differentiation degree，the vascular invasion and drinking patients were associated with treatment failure.This group of patients should develop more intensive followup strategies after surgery，and appropriate postoperative adjuvant treatment may help reduce the risk of recurrence and improve prognosis after surgery.

Key words:  ,  , neoadjuvant chemoradiotherapy, local advanced rectal cancer, pathological complete response