Abstract: Hepatocellular carcinoma is the fifth most common malignant tumor in our country,and hepatectomy is one of the main treatment methods for hepatocellular carcinoma.Pringle maneuver (PM) is widely used in hepatectomy to reduce bleeding,but the maneuver causes ischemia reperfusion injury.Prolonged use of PM may affect liver function and increase postoperative complications,especially in patients with cirrhosis.PM may also accelerate the growth of micrometastatic tumor cells in the liver and promote tumor metastasis.However,the safe duration and methods of PM usage,as well as whether it shortens the disease-free survival or overall survival of patients undergoing liver resection for hepatocellular carcinoma,remain controversial.This article summarizes the effect of Pringle maneuver on the prognosis of patients with hepatocellular carcinoma during hepatectomy.

Key words: hepatocellular carcinoma; hepatectomy; Pringle maneuver; prognosis