血清烟酰胺腺嘌呤二核苷酸磷酸氧化酶2水平与动脉瘤性蛛网膜下腔出血病人脑组织血供及预后的相关性

摘要/Abstract

参考文献

相关文章 15

Metrics

doi:10.3969/j.issn.1005-6483.20240455

摘要： 目的探讨血清烟酰胺腺嘌呤二核苷酸磷酸氧化酶2（nicotinamide adenine dinucleotide phosphate oxidase，NOX2）水平与动脉瘤性蛛网膜下腔出血（aneurysmal subarachnoid hemorrhage，aSAH）病人脑组织血供及预后的相关性。方法 2021年1月~2023年12月收治的150例aSAH病人作为观察组，同期选择65例本院健康体检者为对照组，经颅多普勒超声检测大脑中动脉（MCA）及大脑前动脉（ACA)的血流速度（Vm），检测病人及健康体检者血清NOX2的表达水平。Pearson相关性分析血清NOX2水平与MCA及ACAVm血流速度的相关性。随访90天，将其分为预后良好组（98例）和预后不良组（52例）；多因素Logistic回归分析aSAH病人预后不良的相关因素，绘制ROC曲线分析相关因素的预测效能。结果观察组与对照组的血清NOX2分别为（2185.20±231.15）pg/ml、（1025.31±98.24）pg/ml，MCA的Vm分别为（64.30±8.22）cm/s、（89.16±9.14）cm/s，ACA的Vm分别为（39.20±3.04）cm/s、（51.03±9.35）cm/s，两组比较差异有统计学意义（P<0.05）。Pearson相关性分析显示，aSAH病人血清NOX2水平与MCA及ACA的Vm均呈负相关（r=-0.512/-0.219，P<0.05）。预后不良组与预后良好组的WBC分别为（9.96±2.76）×10⁹/L、（8.35±2.51）×10⁹/L，血糖水平分别为（8.16±2.05）mmol/L、（7.18±1.89）mmol/L，NOX2水平分别为（2278.30±215.26）pg/ml、（1985.36±221.34）pg/ml，改良Fisher评分分别为（3.02±0.98）分、（2.12±0.61）分，WFNS评分分别为（4.01±0.84）分、（2.16±0.72）分，急性脑积水占比分别为25.00%、9.18%，两组比较差异有统计学意义（P<0.05）。多因素Logistic回归分析显示，NOX2水平（OR=1.008）和改良Fisher评分（OR=6.329）是aSAH病人预后不良的独立危险因素（P<0.05）。ROC曲线结果显示，NOX2水平、改良Fisher评分的曲线下面积（area under curve，AUC）分别为0.844（95%CI：0.776~0.898），0.691（95%CI：0.611~0.764）。结论 aSAH病人呈现较高血清NOX2水平，且与脑组织血供存在密切联系；血清NOX2水平和改良Fisher评分是aSAH病人预后不良的独立危险因素，且血清NOX2水平具有更好的预测效能，有待作为预测aSAH病人不良预后的有效指标。

关键词: 烟酰胺腺嘌呤二核苷酸磷酸氧化酶2, 动脉瘤性蛛网膜下腔出血, 预后, 脑组织血供

Abstract: Objective To investigate the correlation between serum nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) level and cerebral blood supply and prognosis in patients with aneurysm al subarachnoid hemorrhage (aSAH).Methods 150 patients with aSAH admitted to our hospital from January 2021 to December 2023 were selected retrospectively as the observation group (150 cases),and 65 healthy people in our hospital were selected as the control group (65 cases) during the same period.Pearson correlation coefficient was used to analyze the correlation between serum NOX2 level and blood flow velocity of middle cerebral artery (MCA) and anterior cerebral artery (ACA).After 90 days of follow-up,according to the prognosis of aSAH patients,they were divided into good prognosis group (98 cases) and poor prognosis group (52 cases).Multivariate Logistic regression was used to analyze the related factors of poor prognosis in aSAH patients,and ROC curve was drawn to analyze the predictive efficacy of related factors.Results The serum NOX2 of the observation group and the control group were (2 185.20±231.15)pg/ml and (1 025.31±98.24)pg/ml,the Vm of MCA was (64.30±8.22)cm/s and (89.16±9.14)cm/s,and the Vm of ACA was (39.20±3.04)cm/s and (51.03±9.35)cm/s,respectively.The difference between the two groups was statistically significant(P<0.05).Pearson correlation coefficient analysis showed that the serum NOX2 level of aSAH patients was negatively correlated with the Vm of MCA and ACA (r=-0.512/-0.219,P<0.05).The WBC of the poor prognosis group and the good prognosis group were (9.96±2.76)×10⁹/L and (8.35±2.51)×10⁹/L,the blood sugar level was (8.16±2.05)mmol/L and (7.18±1.89)mmol/L,the NOX2 level was (2 278.30±215.26)pg/ml and (1 985.36±221.34)pg/ml,the improved Fisher score was (3.02±0.98) and (2.12±0.61),the WFNS score was (4.01±0.84) and (2.16±0.72),and the proportion of acute hydrocephalus was 25.00% and 9.18%,respectively.The difference between the two groups was statistically significant(P<0.05).Multivariate Logistic regression analysis showed that NOX2 level (OR=1.008) and improved Fisher score (OR=6.329) were independent risk factors for poor prognosis of aSAH patients (P<0.05).The ROC curve shows that the NOX2 level and the area under curve (AUC) of the improved Fisher score are 0.844 (95%CI: 0.776~0.898) and 0.691 (95%CI: 0.611~0.764) respectively.Conclusion aSAH patients have higher serum NOX2 level,which is closely related to the blood supply of brain tissue.Serum NOX2 level and improved Fisher score are independent risk factors for poor prognosis of patients with aSAH,and serum NOX2 level has better predictive efficacy,which needs to be used as an effective index to predict poor prognosis of patients with aSAH.

Key words: nicotinamide adenine dinucleotide phosphate oxidase 2, aneurysmal subarachnoid hemorrhage, prognosis, blood supply of brain tissue

林锦超郁毅刚. 血清烟酰胺腺嘌呤二核苷酸磷酸氧化酶2水平与动脉瘤性蛛网膜下腔出血病人脑组织血供及预后的相关性[J]. 临床外科杂志, 2025, 33(2): 134-138.

LIN Jinchao, YU Yigang. Correlation between serum nicotinamide adenine dinucleotide phosphate oxidase 2 level and cerebral blood supply and prognosis in patients with aneurysmal subarachnoid hemorrhage[J]. JOURNAL OF CLINICAL SURGERY, 2025, 33(2): 134-138.

[1]	陈壮赵心恺王文君邱珊珊. 胃癌病人组织中环指跨膜蛋白2、微纤维相关蛋白2(MFAP2)、AF4/FMR2家族成员3表达与肿瘤病理特征及预后的相关性分析[J]. 临床外科杂志, 2025, 33(2): 144-148.
[2]	赵国栋, 黄刚. 肾移植受者BK多瘤病毒感染临床诊疗国际指南(第2版)解读[J]. 临床外科杂志, 2025, 33(1): 63-66.
[3]	彭蓉蓉, 卞家蓉, 谈王蓉. 血清神经元特异性烯醇化酶、基质细胞衍生因子1和诱饵受体3联合在非小细胞肺癌病人预后评估中的临床意义[J]. 临床外科杂志, 2025, 33(1): 92-96.
[4]	严萍萍, 张绍东, 郭皎亮, 窦燕东. Luminal B型乳腺癌组织中XAF1、PCK1表达及与病人预后的关系[J]. 临床外科杂志, 2025, 33(1): 97-101.
[5]	李林, 陈楚鹰, 何久圣, 张浩. 切开复位内固定术联合韧带修复治疗踝关节骨折合并下胫腓前韧带断裂的疗效分析[J]. 临床外科杂志, 2025, 33(1): 105-108.
[6]	秦乐衡怡鑫徐佳鑫黄宁邓胜和古俊楠毛富巍薛一凡蒋振兴王军程登龙曹英豪蔡开琳. 结直肠癌合并肝骨转移病人预后评分系统的开发和验证：一项回顾性队列研究[J]. 临床外科杂志, 2024, 32(9): 947-954.
[7]	于青郑媛媛张莉张志华. 药物涂层球囊经皮腔内血管成形术对下肢动脉长段闭塞病人临床指标及预后的影响[J]. 临床外科杂志, 2024, 32(9): 976-979.
[8]	康树宏吕峰倪云峰贠俊茹. 微小核糖核酸-27a、微小核糖核酸-1299预测食管癌病人术后预后的临床价值[J]. 临床外科杂志, 2024, 32(8): 803-806.
[9]	王娜孙伟伟邢国靖赵金雷孙群. 血清基质金属蛋白酶-9、热休克蛋白47水平与急性脑出血术后预后的关系[J]. 临床外科杂志, 2024, 32(8): 818-821.
[10]	何朝滨李升平. 不可逆电穿孔治疗胰腺癌[J]. 临床外科杂志, 2024, 32(7): 673-676.
[11]	徐业成傅德良. 胰腺全切除术在胰腺癌治疗中的应用[J]. 临床外科杂志, 2024, 32(7): 677-679.
[12]	冯南林鸿千郭义锦王亚娇. 食管印戒细胞癌病人预后不良危险因素分析及列线图预测模型构建[J]. 临床外科杂志, 2024, 32(7): 712-715.
[13]	路慧青赵友为刘巍. 膀胱癌病人血清miR-143-3p、ATG2B水平与临床病理及预后生存的关系[J]. 临床外科杂志, 2024, 32(7): 757-761.
[14]	尹英爱秦桂萍华玉兰曹敏齐淋喆白苏日娜杨悦. 伴AFP明显升高的高级别胎儿型肺腺癌一例[J]. 临床外科杂志, 2024, 32(6): 619-620.
[15]	孙杨王豪马腾刘永吉苗丹石岭. 静脉溶栓联合Trevo支架机械取栓治疗缺血性脑卒中的疗效及影响因素分析[J]. 临床外科杂志, 2024, 32(5): 468-471.

Just accepted

Online first

Just accepted

Online first

Viewed

Full text

	From	local

	Times	31
	Rate	100%

Abstract

Just accepted	Online first	Issue

0	0	61

From	Others	local

Times	60	1
Rate	98%	2%

Cited

Web of Science	Crossref	ScienceDirect	Search for Citations in Google Scholar >>


This page requires you have already subscribed to WoS.

Shared

Discussed