胃癌病人组织中环指跨膜蛋白2、微纤维相关蛋白2(MFAP2)、AF4/FMR2家族成员3表达与肿瘤病理特征及预后的相关性分析

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doi:10.3969/j.issn.1005-6483.20240211

摘要： 目的探讨胃癌(GC)病人组织中环指跨膜蛋白2(RNFT2)、微纤维相关蛋白2(MFAP2)、AF4/FMR2家族成员3(AFF3)表达与肿瘤病理特征及预后的相关性。方法收集2018年5月~2020年1月期间在本院手术的98例GC病人术中切除的GC组织标本和癌旁组织标本。采用免疫组织化学法检测RNFT2、MFAP2、AFF3的表达；采用Kaplan-Meier法分析RNFT2、MFAP2、AFF3表达与GC病人预后的关系；多因素Cox回归分析GC病人预后的影响因素。结果与癌旁组织相比，GC组织中RNFT2、MFAP2蛋白的阳性率明显较高，AFF3蛋白的阳性率明显较低(P<0.05)。RNFT2、MFAP2、AFF3蛋白表达与TNM分期、分化程度显著相关(P<0.05)；Kaplan-Meier分析显示，RNFT2、MFAP2阳性表达病人3年生存率分别低于RNFT2、MFAP2阴性表达病人，AFF3阳性表达病人3年生存率高于AFF3阴性表达病人(P＜0.05)。RNFT2、MFAP2、AFF3、TNM分期、分化程度是GC者预后的影响因素。结论 GC组织中RNFT2、MFAP2显著高表达，AFF3显著低表达，与TNM分期、分化程度等临床病理特征和预后密切相关，且对GC病人预后生存情况有重要价值。

关键词: 环指跨膜蛋白2, 微纤维相关蛋白2, AF4/FMR2家族成员3, 胃癌, 病理特征, 预后

Abstract: Objective To investigate the expression of RNFT2,MFAP2,and AF4/FMR2 family member 3 (AFF3) in gastric cancer(GC) tissues,and to analyze their correlation with tumor pathological features and prognosis.Methods GC tissue specimens and adjacent tissue specimens were collected from 98 GC patients who underwent surgery in our hospital from May 2018 to January 2020,clinical data were also collected.Immunohistochemical methods were applied to detect the expression of RNFT2,MFAP2,and AFF3;Kaplan-Meier method was applied to analyze the relationship between the expression of RNFT2,MFAP2,and AFF3 and the prognosis of GC patients;multivariate Cox regression was applied to analyze the influencing factors of prognosis in GC patients.Results Compared with adjacent tissues,the positive rates of RNFT2 and MFAP2 proteins in GC tissue were obviously higher（75.51% vs. 29.59%,70.41% vs.19.39%),while the positive rate of AFF3 protein was obviously lower (26.53% vs. 68.37%,P<0.05).The expression of RNFT2,MFAP2,and AFF3 proteins was obviously correlated with TNM staging and differentiation degree (P<0.05);Kaplan-Meier method showed that the 3 year survival rates of RNFT2 and MFAP2 positive expression patients were lower than those of RNFT2 and MFAP2 negative expression patients,respectively,the 3year survival rate of AFF3 positive expression patients was higher than that of AFF3 negative expression patients (P<0.05).Multivariate Cox regression analysis showed that RNFT2,MFAP2,AFF3,TNM staging,and differentiation degree were prognostic factors for GC patients.Conclusion RNFT2 and MFAP2 are obviously upregulated in GC tissue,while AFF3 is obviously downregulated,which is closely related to clinical pathological features (such as TNM staging and differentiation) and prognosis,and has important value for the prognosis and survival of GC patients.

Key words: ring finger transmembrane protein 2, microfibrillar associated protein 2, AF4/FMR2 family member 3, gastric cancer, pathological features, prognosis

陈壮赵心恺王文君邱珊珊. 胃癌病人组织中环指跨膜蛋白2、微纤维相关蛋白2(MFAP2)、AF4/FMR2家族成员3表达与肿瘤病理特征及预后的相关性分析[J]. 临床外科杂志, 2025, 33(2): 144-148.

CHEN Zhuang, ZHAO Xinkai, WANG Wenjun, QIU Shanshan. Correlation analysis of RNFT2,MFAP2,and AFF3 expression with tumor pathological features and prognosis in gastric cancer patients[J]. JOURNAL OF CLINICAL SURGERY, 2025, 33(2): 144-148.

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