关键词: 结直肠癌, 整合素α5, 整合素β1, 整合素β2, 预后

Abstract: Objective To investigate the significance and prognostic value of integrin α5,β1 and β2 in colorectal cancer (CRC).Methods The clinical data of 187 patients with CRC who were diagnosed in the hospital from January 2017 to January 2018 were analyzed retrospectively.The expression of integrin α5,β1 and β2 in cancer tissues and adjacent tissues,and its relationship with pathological characteristics of CRC were analyzed.All patients were followed up for 5 years after operation.Postoperative recurrence and survival time were recorded.Results The positive expression rates of integrin α5,β1 and β2 in cancer tissues were higher than adjacent tissues (P<0.05).There was no statistically significant difference in the expression levels of integrin α5,β1 and β2 in patients of different gender,patients of different age and patients with different tumor diameters (P>0.05).The expression levels of integrin α5,β1 and β2 in patients with different differentiation degrees,patients in different TNM stages,and patients with and without lymph node metastasis were significantly different (P<0.05).All of the 187 patients were followed up for 5 years,without any case lost to follow-up,and a total of 84 patients had recurrence.The positive expression rates of integrin α5,β1 and β2 in patients with recurrence were higher than those in patients without (P<0.05).The average survival time and survival rate of patients with positive expression of integrin α5,β1 and β2 were shorter/lower than those of patients with negative expression (P<0.05).Conclusion The positive expression rates of integrin α5,β1 and β2 in CRC patients are increased.They are closely related to differentiation degree,TNM stage and lymph node metastasis,and influence postoperative recurrence and survival time of the patients.Therefore,the above indicators can be used for prognosis.

Key words: colorectal cancer, integrin α5, integrin β1, integrin β2, prognosis