临床外科杂志 ›› 2024, Vol. 32 ›› Issue (5): 472-475.doi: 10.3969/j.issn.1005-6483.2024.05.008

• 论著 • 上一篇    下一篇

重型颅脑损伤病人血清微小RNA-542-3p、长链非编码RNA牛磺酸上调基因1表达及其与预后的关系

  

  1. 048400   山西省高平市人民医院神经外科
  • 收稿日期:2023-04-23 修回日期:2023-04-23 接受日期:2023-04-23 出版日期:2024-05-25 发布日期:2024-05-25
  • 通讯作者: 李帆,Email:jinniud377@163.com

The expression of miR-542-3p and long chain non-coding RNA taurine up-regulated gene 1 in serum of patients with severe traumatic brain injury and their relationship with prognosis

  1. Department of Neurosurgery,Gaoping People’s Hospital,Shanxi,Jincheng 048400,China
  • Received:2023-04-23 Revised:2023-04-23 Accepted:2023-04-23 Online:2024-05-25 Published:2024-05-25

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摘要： 目的  探讨微小RNA-542-3p(miR-542-3p)、长链非编码RNA牛磺酸上调基因1(lncRNA TUG1)在重型颅脑损伤(STBI)病人血清中的表达及与病人预后的关系。方法 2020年1月~2022年7月收治的128例STBI病人为重型组，130例轻、中型TBI病人为对照组，检测病人血清miR-542-3p、lncRNA TUG1表达量，采用Pearson法分析二者相关性。Logistic回归分析血清miR-542-3p、lncRNA TUG1对STBI病人预后不良的影响，并以受试者工作特征(ROC)曲线分析二者对STBI病人预后的预测效能。结果  重型组病人血清miR-542-3p与lncRNA TUG1表达量分别低于和高于对照组，差异有统计学意义(P＜0.05)。STBI病人血清miR-542-3p与lncRNA TUG1表达量呈负相关(r=-0.595，P＜0.001)。预后不良组血清lncRNA TUG1与miR-542-3p水平分别高于和低于预后良好组，差异有统计学意义(P＜0.05)。高lncRNA TUG1水平是STBI病人预后不良的危险因素(P＜0.05)，高miR-542-3p水平是保护因素(P＜0.05)。血清miR-542-3p、lncRNA TUG1联合预测STBI病人预后的曲线下面积(AUC)(0.939)高于单独预测的AUC(Z=2.410，P=0.016；Z=3.339，P＜0.001)。结论  STBI病人血清miR-542-3p表达下调，lncRNA TUG1表达上调，二者均可用于STBI病人预后预测，且二者联合的预测价值更高。

关键词: 重型颅脑损伤, 微小RNA-542-3p, 长链非编码RNA牛磺酸上调基因1, 预后

Abstract: Objective  To investigate the expression of microRNA-542-3p (miR-542-3p) and long non-coding RNA taurine up-regulated gene 1 (lncRNA TUG1) in the serum of patients with severe traumatic brain injury (STBI) and their relationship with the prognosis of patients.Methods From January 2020 to July 2022, 128 STBI patients were collected as the severe group and 130 patients with mild or moderate TBI were collected as the control group,retrospectively.The expression levels of miR-542-3p and lncRNA TUG1 in serum were detected and the correlation between them was analyzed.Logistic regression was used to analyze the influencing of serum miR-542-3p and lncRNA TUG1 expression on the poor prognosis of STBI patients,and the predictive efficacy of them on the prognosis of STBI patients was analyzed by receiver operating characteristic (ROC) curve.Results  The serum miR-542-3p and lncRNA TUG1expression level in the severe group were lower and higher than that in the control group,respectively(P＜0.05).The serum miR-542-3p was negatively correlated with lncRNA TUG1 in STBI patients (r=-0.595,P＜0.001).The serum lncRNA TUG1 and miR-542-3p level in poor prognosis group were higher and lower than than that in good prognosis group,respectively(P＜0.05).High lncRNA TUG1 level was risk factor for poor prognosis in STBI patients (P＜0.05),while high miR-542-3p level was a protective factor (P＜0.05).The area under the curve (AUC) (0.939) of serum miR-542-3p and lncRNA TUG1 for predicting the prognosis of STBI patients in combination was higher than that of single prediction (Z=2.410,P=0.016;Z=3.339,P＜0.001).Conclusion  The expression of miR-542-3p in serum of STBI patients is down-regulated,while the expression of lncRNA TUG1 is up-regulated.Both of them can be used for predicting the prognosis of STBI patients,and the combination of the two has higher predictive value.

Key words: severe traumatic brain injury, micro RNA-542-3p, long chain non-coding RNA taurine up-regulated gene 1, prognosis

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