关键词: 非小细胞肺癌, 神经元特异性烯醇化酶, 基质细胞衍生因子1, 诱饵受体3, 预后

Abstract: [Abstract]Objective To analyze the expression levels of neuron specific enolase (NSE),stromal cell derived factor-1 (SDF-1) and decoy receptor 3 (DcR3) in serum of patients with non-small cell lung cancer (NSCLC) and their prognostic value.Methods From March 2019 to March 2020,132 NSCLC patients admitted to Yixing Hospital of Traditional Chinese Medicine and the People’s Hospital of Subei were collected as the study subjects (NSCLC group),another 132 healthy examinees who came to our hospital were as the control group.enzyme linked immunosorbent assay (ELISA) was applied to detect the expression levels of NSE,SDF-1,and DcR3 in serum;multivariatenLogisticn regression was applied to analyze the influencing factors of poor prognosis in NSCLC patients; and receiver operating characteristic (ROC) curve was applied to analyze the value of serum NSE,SDF-1,and DcR3 expression levels in evaluating the prognosis of NSCLC patients.ResultsThe expression levels of NSE,SDF-1,and DcR3 in the serum of the NSCLC group were obviously higher than those of the control group,with statistical significance ( P<0.05);the expression levels of NSE,SDF-1,and DcR3 in the serum of NSCLC patients with a tumor diameter of ≥ 3 cm,low tumor differentiation,TNM staging of stage Ⅲ-Ⅳ,and lymph node metastasis were obviously higher than those of NSCLC patients with a tumor diameter of<3 cm,high/medium tumor differentiation,TNM staging of stage Ⅰ-Ⅱ,and no lymph node metastasis ( P<0.05);compared with the good prognosis group,the expression levels of NSE,SDF-1,and DcR3 in the serum of NSCLC patients in poor prognosis groupwere obviously increased,and the proportion of lymph node metastasis was obviously increased( P<0.05);the results of multivariatenLogisticn regression analysis showed that NSE,SDF-1,DcR3,and lymph node metastasis were the influencing factors for poor prognosis in NSCLC patients ( P<0.05);the results of receiver operating characteristic analysis showed that the area under the curve (AUC) of serum NSE,SDF-1 and DcR3 levels in evaluating prognosis of NSCLC patients was 0.852,which was more valuable than the single index of NSE,SDF-1 and DcR3.Conclusion The expression levels of NSE,SDF-1,and DcR3 in the serum of NSCLC patients are obviously increased,and the combination of the three can be used as a prognostic indicator for NSCLC patients.

Key words: nonsmall cell lung cancer, neuronspecific enolase, stromal cellderived factor 1, decoy receptor 3, prognosis