临床外科杂志 ›› 2022, Vol. 30 ›› Issue (12): 1196-1199.doi: 10.3969/j.issn.1005-6483.2022.12.028

• 综述与讲座 • 上一篇    下一篇

外泌体在增生性瘢痕和瘢痕疙瘩治疗中的研究进展

  

  1. 430060 武汉大学人民医院整形美容外科(陶瑞,谭植襄,李思成、余墨声、朱占永);武汉大学附属同仁医院暨武汉市第三医院烧伤科(张伟,阮晶晶)
  • 收稿日期:2022-11-20 接受日期:2022-11-20 出版日期:2022-12-20 发布日期:2023-01-20
  • 通讯作者: 朱占永,Email:zyzhu@whu.edu.cn
  • 基金资助:
    湖北省卫生健康科研基金(WJ2021F106)

The research progress of exosome in the treatment of hypertrophic scar and keloid

  1. Department of Plastic and Aesthetic Surgery,Wuhan University People's Hospital,Wuhan 430060,China
  • Received:2022-11-20 Accepted:2022-11-20 Online:2022-12-20 Published:2023-01-20

摘要: 在人体创伤修复过程的终末阶段,常会伴随瘢痕的产生。当机体有序的修复过程被打破,创面异常愈合,便可能产生增生性瘢痕、瘢痕疙瘩,给病人带来身心负担的同时,也会造成大量医疗资源的消耗。临床上瘢痕主要通过外科手术、局部放射、药物注射等方式治疗,但其疗效与预期仍存在差距,探求新的治疗方案具有重要意义。有研究表明,外泌体对瘢痕有一定治疗作用。本综述将总结外泌体用于增生性瘢痕和瘢痕疙瘩治疗的作用机制及研究进展。

关键词: 外泌体, 增生性瘢痕, 瘢痕疙瘩, 瘢痕治疗

Abstract: In the terminal stage of the human wound repair process,it is often accompanied by scar formation.Hypertrophic scar and keloid may occur when the orderly repair process of the body is broken and the wound heals abnormally.The emergence of them not only brings physical and mental burden to patients,but also consumes a lot of medical resources.Clinically,scar is mainly treated by surgery,local radiation and drug injection,but there is still a little gap between its curative effect and expectation.Therefore,it is of great significance to explore new treatment methods.Existing studies have shown that exosomes  have a certain therapeutic effect on scar.This review will summarize the mechanism and recent research progress of exosome in the treatment of hypertrophic scar and keloid.

Key words: exosome, hypertrophic scar, keloid, scar treatment

[1] 袁泳锨 庾建中 王永霞. 乳腺癌细胞外泌体miR-27a对巨噬细胞极化及肿瘤生长和转移的影响[J]. 临床外科杂志, 2022, 30(2): 149-154.
[2] 徐若清 黄昕 李青峰 昝涛. 病理性瘢痕研究中的困惑和突破[J]. 临床外科杂志, 2022, 30(12): 1104-1107.
[3] 熊光冰 王敏 朱峰 秦仁义. 液态活检在胰腺癌早期诊断中的作用[J]. 临床外科杂志, 2021, 29(7): 679-683.
[4] 刘坤 吴河水. 胰腺癌免疫治疗现状及进展[J]. 临床外科杂志, 2021, 29(7): 687-690.
[5] 徐正芹 李杨 刘汪旺 叶柳. 急性颅脑损伤病人血清外泌体中泛素碳末端水解酶L1和神经丝蛋白轻链多肽的表达及意义[J]. 临床外科杂志, 2021, 29(10): 926-929.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] 胡善彪;余少杰;彭龙开. 婴幼儿供肾移植[J]. 临床外科杂志, 2016, 24(10): 741 .
[2] 齐卫鹏;王剑明;刘颜;等. 术前应用靛氰绿检测联合三维重建成像评估肝门部胆管癌肝脏储备功能[J]. 临床外科杂志, 2016, 24(10): 756 .
[3] 李光焰;张安平;王祥峰;等. 直肠癌切除术后吻合口狭窄14例分析[J]. 临床外科杂志, 2016, 24(10): 772 .
[4] 刘琼;江辉. 喉罩在小儿舌系带矫正手术中的应用[J]. 临床外科杂志, 2016, 24(10): 792 .
[5] 余兰;聂秀. 脾脏硬化性血管瘤样结节性转化二例[J]. 临床外科杂志, 2016, 24(10): 808 .
[6] 涂儒鸿;黄昌明. 腹腔镜胃癌根治术淋巴结清扫技巧[J]. 临床外科杂志, 2016, 24(11): 809 .
[7] 曹志新. 基于膜解剖的胃癌D2手术[J]. 临床外科杂志, 2016, 24(11): 812 .
[8] 石汉平. 胃癌围手术期营养治疗[J]. 临床外科杂志, 2016, 24(11): 821 .
[9] 林伟箭;洪雪辉;许淑镇;等. 吸引器在腹腔镜胃癌根治术中的应用体会[J]. 临床外科杂志, 2016, 24(11): 824 .
[10] 吴川清;刘炜圳;帅晓明;等. 超声内镜在胃癌术前诊断中的应用分析[J]. 临床外科杂志, 2016, 24(11): 828 .