关键词: 阿托伐他汀, 骨质疏松性骨折, 活化T细胞核因子

Abstract: Objective To observe the effect of atorvastatin on the healing of osteoporotic fractures(OPF) in rats and related mechanisms.Methods Forty rats were established OPF models.They were randomly divided into model group,experimental-A group,experimental B group,and experimentalC group,each with 10 rats.Experimental A,B,and C groups were given atorvastatin 10,20,and 40 mg·kg-1 respectively,and the model group was given an equal volume of normal saline.The fracture healing in rats were observed by X-ray film.The biomechanical properties of callus were detected by biomechanical test.The protein expression of activated T cell nuclear factor 1(NFATc1) and osteoclast-associated receptor(OSCAR),osteocalcin(OCN),collagen Type I(COL-I) in the callus tissue were detect by Western blotting.Results Compared with the model group,the X-ray scores of experimental-A group was increased,the maximum load and stiffness was increased,the protein expressions of NFATc1 and OSCAR were decreased,and the protein expressions of OCN and COL-I were increased(P＜0.05)，and ot was dose-dependent.Conclusion Atorvastatin can promote the healing of OPF in rats and enhance the biomechanical properties.It is speculated that its mechanism of action is related to the inhibition of the NFATc1 signaling pathway.

Key words: atorvastatin, osteoporotic fracture, activated T cell nuclear factor 1