不同抗血小板策略对高血压合并2型糖尿病病人冠脉搭桥术后桥血管通畅率的影响

doi:10.3969/j.issn.1005-6483.2022.05.012

临床外科杂志 ›› 2022, Vol. 30 ›› Issue (5): 444-446.doi: 10.3969/j.issn.1005-6483.2022.05.012

不同抗血小板策略对高血压合并2型糖尿病病人冠脉搭桥术后桥血管通畅率的影响

116033 大连市中心医院心脏大血管外科

收稿日期:2021-08-09 接受日期:2021-08-09 出版日期:2022-05-20 发布日期:2022-06-20
通讯作者: 庄熙晶，Email：dlmchcsd@126.com

Comparative study on the effect of different antiplatelet strategy on the patency of bypass grafts after CABG in patients with hypertension complicated with diabetes

Department of Cardiovascular Surgery,Dalian Municipal Central Hospital，Liaoning，Dalian 116033,China

Received:2021-08-09 Accepted:2021-08-09 Online:2022-05-20 Published:2022-06-20

摘要/Abstract

摘要： [摘要] 目的 比较替格瑞洛/氯吡格雷对高血压合并2型糖尿病病人冠脉搭桥术后1年桥血管的影响。方法 2016年3月～2020年8月我院行冠脉搭桥术病人78例，随机分为两组，A组41例，采用氯吡格雷治疗，B组37例，采用替格瑞洛治疗。术后1年行CTA检查评估桥血管情况，并随访不良事件。结果两组一般资料、总桥血管及动脉桥血管通畅率、心绞痛、出血事件比较，差异无统计学意义(P>0.05)。B组静脉桥血管通畅率显著高于A组(89.2% vs.76.8%，P=0.042)。Logistic回归分析显示，替格瑞洛可降低桥血管狭窄风险(OR=2.488，95%CI：1.016~6.091，P=0.046)。结论冠脉搭桥术后1年，替格瑞洛可更好地维持高血压病合并2型糖尿病病人桥血管通畅。

关键词: 冠脉搭桥术, 高血压病, 2型糖尿病, 替格瑞洛, 氯吡格雷

Abstract: [Abstract] Objective To compare effects of ticagrelor/clopidogrel on bypass in patients with hypertension complicated with diabetes 1 year after CABG.Methods 78 patients undergoing CABG in our hospital from March 2016 to August 2020 were selected and divided into group A(clopidogrel) and group B(ticagrelor).CTA was performed 1 year after the operation to assess bypass,and adverse events were followed up.Results There were no significant differences in general data,total/arterial bridge vessel patency,angina and bleeding events between 2 groups(P>0.05).The patency of vein bypass in group B was significantly higher than group A(76.8%vs.89.2%,P=0.042).Logistic regression suggested that ticagrelor reduced the risk of bridging stenosis(OR=2.488,95%CI:1.016-6.091,P=0.046).〖WTHZ〗Conclusion 1 year after CABG,ticagrelor better maintained bridge patency in hypertensive patients with type 2 diabetes.

Key words: coronary artery bypass grafting, hypertension, type 2 diabetes mellitus, ticagrelor, clopidogrel

高洋王文君高峰石磊刘巍何学志庄熙晶. 不同抗血小板策略对高血压合并2型糖尿病病人冠脉搭桥术后桥血管通畅率的影响[J]. 临床外科杂志, 2022, 30(5): 444-446.

GAO Yang, WANG Wenjun, GAO Feng, et al. Comparative study on the effect of different antiplatelet strategy on the patency of bypass grafts after CABG in patients with hypertension complicated with diabetes[J]. JOURNAL OF CLINICAL SURGERY, 2022, 30(5): 444-446.

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不同抗血小板策略对高血压合并2型糖尿病病人冠脉搭桥术后桥血管通畅率的影响

Comparative study on the effect of different antiplatelet strategy on the patency of bypass grafts after CABG in patients with hypertension complicated with diabetes

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