关键词: 轻型颅脑损伤, 高迁移率族蛋白B1, 泛素C末端水解酶L1, 神经元特异性烯醇化酶, 预后

Abstract: Objective To investigate the changes of serum high mobility group protein B1(HMGB1),ubiquitin C-terminal hydrolase L1(UCH-L1) and neuron-specific enolase(NSE) levels in patients with mild head injury(MHI) and correlation with prognosis.
Methods A total of 84 MHI patients admitted to our hospital(January 2017 to January 2019) were selected as the MHI group,according to the Glasgow Outcome Scale(GOS),it is divided into a poor prognosis group(n=23) and a good prognosis group(n=61),in addition,57 healthy patients who came to our hospital for physical examination during the same period were selected as the control group.Compare the serum HMGB1,UCH-L1,and NSE levels in each group,Multivariate Logistics regression analysis of factors affecting the prognosis of MHI patients,ROC analyzes the predictive value of serum HMGB1,UCH-L1,and NSE levels for the poor prognosis of MHI patients.
Results The levels of serum HMGB1,UCH-L1,and NSE in the MHI group were significantly higher than those in the control group(P<0.05).The proportion of complex injuries,complications and serum HMGB1,UCH-L1 and NSE levels in the poor prognosis group were significantly higher than those in the good prognosis group(P<0.05).Compound damage,HMGB1,UCH-L1,NSE were independent factors influencing the poor prognosis of MHI patients(P<0.05).The ROC curve shows that the AUC of HMGB1+UCH-L1+NSE predicting the poor prognosis of MHI is significantly greater than that of HMGB1,UCH-L1,NSE were predicted separately.
Conclusion The serum levels of HMGB1, UCH-L1 and NSE in MHI patients were significantly increased, which were closely related to the prognosis. Combined detection could improve the prognostic value of MHI.

Key words: mild head injury, high mobility group protein B1, ubiquitin C-terminal hydrolase L1, neuron-specific enolase, prognosis