磷脂酰肌醇3-激酶p110α/β在甲状腺乳头状癌组织中的表达及与预后的相关性

doi:10.3969/j.issn.1005-6483.2021.01.026

摘要/Abstract

摘要： 目的检测甲状腺乳头状癌病人癌组织中磷脂酰肌醇3-激酶(phosphatidylinositol 3-kinase，PI3K)p110α、PI3Kp110β表达水平及其与预后的关系。
方法 2008年1月～2013年7月我院收治的甲状腺乳头状癌病人60例(甲状腺乳头状癌组)，结节性甲状腺肿60例(结节性甲状腺肿组)，其他非癌病例正常甲状腺组织60例(正常组)。随访甲状腺乳头状癌组5年生存情况。免疫组化检测各组PI3Kp110α、PI3Kp110β蛋白表达情况，Kaplan-Meier生存曲线分析甲状腺乳头状癌病人PI3Kp110α、PI3Kp110β阳性组和阴性组生存情况，Spearman法分析PI3Kp110α与PI3Kp110β的相关性。
结果分别与正常组、结节性甲状腺肿组相比，甲状腺乳头状癌组PI3Kp110α、PI3Kp110β阳性率升高(P＜0.05)。甲状腺乳头状癌病人癌组织PI3Kp110α、PI3Kp110β阳性表达与肿瘤大小、淋巴结转移情况、TNM分期明显相关(P＜0.05)。单因素分析显示，PI3Kp110α、PI3Kp110β、淋巴结转移、TNM分期均为影响甲状腺乳头状癌预后不良的危险因素；多因素分析显示，PI3Kp110α、PI3Kp110β、淋巴结转移、TNM分期均是影响甲状腺乳头状癌预后不良的独立危险因素。60例病人14例出现复发，无失访病例。PI3Kp110α、PI3Kp110β阳性累计生存率明显低于PI3Kp110α、PI3Kp110β阴性累计生存率(P均＜0.05)。Spearman法分析甲状腺乳头状癌病人癌组织中PI3Kp110α与PI3Kp110β呈正相关(P＜0.05)。
结论甲状腺乳头状癌病人癌组织中PI3Kp110α、PI3Kp110β阳性率升高，是预后不良的独立危险因素，且二者关系密切。

关键词: 甲状腺乳头状癌, 磷脂酰肌醇3-激酶p110α, 磷脂酰肌醇3-激酶p110β, 预后

Abstract: Objective To detect the expressions of phosphatidylinositol 3-kinase(PI3K) P110 α and PI3Kp110β in thyroid papillary carcinoma and their relationships with prognosis.
Methods From January 2008 to July 2013,60 cases of thyroid papillary carcinoma(thyroid papillary carcinoma group),60 cases of nodular goiter(nodular goiter group) and 60 cases of other non cancerous cases were collected;the 5-year survival of papillary thyroid carcinoma group was followed up.The expressions of PI3Kp110α and PI3Kp110β protein were detected by immunohistochemistry,Kaplan-Meier survival curve was used to analyze the survival of PI3Kp110α,PI3Kp110β positive and negative groups,and Spearman method was used to analyze the correlation between PI3Kp110α and PI3Kp110β.
Results Compared with the normal group and nodular goiter group,the positive rates of PI3Kp110α and PI3Kp110β were higher in papillary thyroid carcinoma group(P<0.05).The positive expressions of PI3Kp110α and PI3Kp110β were significantly correlated with tumor size,lymph node metastasis and TNM stage(P<0.05).Single factor analysis showed that PI3Kp110α,PI3Kp110β,lymph node metastasis and TNM stage were all risk factors for poor prognosis of thyroid papillary carcinoma;multivariate analysis showed that PI3Kp110α,PI3Kp110β,lymph node metastasis and TNM stage were independent risk factors for poor prognosis of thyroid papillary carcinoma.A total of 14 cases of 60 patients had relapse,and no cases were missed.The positive cumulative survival rates of PI3Kp110α and PI3Kp110β were significantly lower than those of PI3Kp110α and PI3Kp110β(P<0.05).Spearman analysis showed that there was a positive correlation between PI3Kp110α and PI3Kp110β(P＜0.05).
Conclusion The positive rates of PI3Kp110α and PI3Kp110β in thyroid papillary carcinoma are increased,which are independent risk factors for poor prognosis,and they are closely related.

Key words: thyroid papillary carcinoma, phosphatidylinositol 3-kinase p110α, phosphatidylinositol 3-kinase p110β, prognosis

杨晓华吴淑华. 磷脂酰肌醇3-激酶p110α/β在甲状腺乳头状癌组织中的表达及与预后的相关性[J]. 临床外科杂志, 2021, 29(1): 74-77.

YANG Xiaohua, WU Shuhua. Expression of PI3Kp110α/β in papillary thyroid carcinoma and its prognostic correlation[J]. JOURNAL OF CLINICAL SURGERY, 2021, 29(1): 74-77.

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