关键词: 结直肠癌, miR-21, 血管内皮生长因子, 基质金属蛋白酶-9

Abstract: Objective To investigate the relationship between the expression of miR-21,vascular endothelial growth factor (VEGF) and matrix metalloproteinase (MMP)-9 and prognosis in patients with colorectal cancer.
Methods From December 2013 to June 2016,144 cases of patients with colorectal cancer were enrolled in this hospital.All patients were underwent endoscopic radical surgery,and the clinicopathological features were investigated.The prognosis were followed up and given correlation analysis.
Results The positive rates of miR-21,VEGF and MMP-9 in the lesion group were 72.9%,69.4% and 84.0%,which were significantly higher than those in the control group (15.3%,23.6% and 38.9%) (P<0.05).In the 144 patients,the positive expression of miR-21,VEGF and MMP-9 in the lesions were closely related to tumor differentiation,lymph node metastasis,clinical stage and tumor diameter (P<0.05).Follow-up to October 2019,there were 34 patients were deaths that the mortality rates were 23.6%,COX regression model showed that miR-21,VEGF,MMP-9 are the factors that affected the prognosis of colorectal cancer patients (P<0.05).
Conclusion The high expression of miR-21,VEGF and MMP-9 in patients with colorectal cancer are significantly correlated with the pathological features of patients,and miR-21,VEGF and MMP-9 may affect the prognosis of patients.

Key words: colorectal cancer, miR-21, vascular endothelial growth factor, matrix metalloproteinase-9